Thais S Domingues1,2, Ana Paula Aquino3, Bruna Barros3, Raquel Mazetto3, Mariana Nicolielo3, Carolina M Kimati3, Talita Devecchi3, Tatiana C S Bonetti3,4, Paulo C Serafini3,5, Eduardo L A Motta3,4. 1. Huntington - Medicina Reprodutiva, Av Republica do Libano, 529 Ibirapuera, Sao Paulo, 04501-000, Brazil. tdomingues@huntington.com.br. 2. Disciplina de Ginecologia Endocrinológica, Departamento de Ginecologia, Escola Paulista de Medicina da Universidade Federal de Sao Paulo (UNIFESP-EPM), Rua Napoleão de Barros, 608 Vila Clementino, Sao Paulo, SP, 04024-002, Brazil. tdomingues@huntington.com.br. 3. Huntington - Medicina Reprodutiva, Av Republica do Libano, 529 Ibirapuera, Sao Paulo, 04501-000, Brazil. 4. Disciplina de Ginecologia Endocrinológica, Departamento de Ginecologia, Escola Paulista de Medicina da Universidade Federal de Sao Paulo (UNIFESP-EPM), Rua Napoleão de Barros, 608 Vila Clementino, Sao Paulo, SP, 04024-002, Brazil. 5. Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de Sao Paulo (USP), Av. Dr. Arnaldo, 455 Cerqueira César, Sao Paulo, SP, 01246-903, Brazil.
Abstract
PURPOSE: Advances in reproductive techniques, mainly the introduction of oocyte vitrification, have provided the opportunity to conceive from oocyte banks. The aim of this study was to compare the clinical outcomes of fresh and vitrified oocytes in an egg donation program following blastocyst transfer. METHODS: This retrospective observational study included 504 oocyte donation cycles. All donor women were younger than 30 years of age. The recipient cycles were divided into two groups: fresh oocytes (n = 78) or vitrified oocytes (n = 426). All oocytes were fertilized by ICSI using ejaculated sperm, followed by blastocyst transfer. Endometrium preparation was performed with estradiol valerate plus micronized progesterone according to standard protocols. RESULTS: Recipients were of similar age (fresh 42.0 ± 4.5 years vs vitrified 41.8 ± 4.8 years; p = 0.790). The fresh group received more mature oocytes for injection compared to the vitrified group (10.1 ± 2.8 vs 9.2 ± 2.2; p = 0.005). The two pronuclei (2PN) rate (74.5 vs 77.4%; p = 0.195) and blastocyst rate (48.8 vs 51.6%; 0.329) were similar between the fresh and vitrified groups, respectively. The rates of clinical pregnancy were 60.9% in the fresh and 59.0% in the vitrified groups (p = 0.771). CONCLUSIONS: Our findings suggest that vitrified oocytes result in similar pregnancy rates when compared to fresh oocytes with blastocyst transfer in an egg donation program. Moreover, vitrified oocytes may allow for a better cycle schedule, starting with a lower number of oocytes to be fertilized. Therefore, we hypothesize that egg banks with vitrified oocytes could be safely utilized in an egg donation program.
PURPOSE: Advances in reproductive techniques, mainly the introduction of oocyte vitrification, have provided the opportunity to conceive from oocyte banks. The aim of this study was to compare the clinical outcomes of fresh and vitrified oocytes in an egg donation program following blastocyst transfer. METHODS: This retrospective observational study included 504 oocyte donation cycles. All donorwomen were younger than 30 years of age. The recipient cycles were divided into two groups: fresh oocytes (n = 78) or vitrified oocytes (n = 426). All oocytes were fertilized by ICSI using ejaculated sperm, followed by blastocyst transfer. Endometrium preparation was performed with estradiol valerate plus micronized progesterone according to standard protocols. RESULTS: Recipients were of similar age (fresh 42.0 ± 4.5 years vs vitrified 41.8 ± 4.8 years; p = 0.790). The fresh group received more mature oocytes for injection compared to the vitrified group (10.1 ± 2.8 vs 9.2 ± 2.2; p = 0.005). The two pronuclei (2PN) rate (74.5 vs 77.4%; p = 0.195) and blastocyst rate (48.8 vs 51.6%; 0.329) were similar between the fresh and vitrified groups, respectively. The rates of clinical pregnancy were 60.9% in the fresh and 59.0% in the vitrified groups (p = 0.771). CONCLUSIONS: Our findings suggest that vitrified oocytes result in similar pregnancy rates when compared to fresh oocytes with blastocyst transfer in an egg donation program. Moreover, vitrified oocytes may allow for a better cycle schedule, starting with a lower number of oocytes to be fertilized. Therefore, we hypothesize that egg banks with vitrified oocytes could be safely utilized in an egg donation program.
Authors: Zsolt P Nagy; Ching-Chien Chang; Daniel B Shapiro; Diana Patricia Bernal; Carlene W Elsner; Dorothy Mitchell-Leef; Andrew A Toledo; Hilton I Kort Journal: Fertil Steril Date: 2008-08-09 Impact factor: 7.329
Authors: Marjan Van Reckem; Christophe Blockeel; Maryse Bonduelle; Andrea Buysse; Mathieu Roelants; Greta Verheyen; Herman Tournaye; Frederik Hes; Florence Belva Journal: Hum Reprod Open Date: 2021-02-19