Keisuke Ueda1,2, Sandeep Sood2,3, Eishi Asano1,2, Ajay Kumar2,4, Aimee F Luat5,6. 1. Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA. 2. Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI, 48201, USA. 3. Department of Pediatric Neurosurgery, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA. 4. Department of Radiology, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA. 5. Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA. ALuat@dmc.org. 6. Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI, 48201, USA. ALuat@dmc.org.
Abstract
INTRODUCTION: Rett syndrome is a neurodevelopmental genetic disorder, characterized by developmental delay, hand stereotypies, abnormal gait, and acquired microcephaly. Epilepsy is very common in Rett syndrome and can be medically intractable. It remains uncertain if a patient with epileptic drop attacks associated with this genetic disease can benefit from corpus callosotomy. CASE REPORT: We report an 8-year-old girl with Rett syndrome and medically intractable epileptic drop attacks who underwent endoscopic total corpus callosotomy without any complications that led to the successful elimination of her seizures. CONCLUSION: Total corpus callosotomy is a feasible treatment option for medically intractable epileptic drop attacks in Rett syndrome and should not be considered as a contraindication in this condition. This is the first reported case of corpus callosotomy in Rett syndrome.
INTRODUCTION:Rett syndrome is a neurodevelopmental genetic disorder, characterized by developmental delay, hand stereotypies, abnormal gait, and acquired microcephaly. Epilepsy is very common in Rett syndrome and can be medically intractable. It remains uncertain if a patient with epileptic drop attacks associated with this genetic disease can benefit from corpus callosotomy. CASE REPORT: We report an 8-year-old girl with Rett syndrome and medically intractable epileptic drop attacks who underwent endoscopic total corpus callosotomy without any complications that led to the successful elimination of her seizures. CONCLUSION: Total corpus callosotomy is a feasible treatment option for medically intractable epileptic drop attacks in Rett syndrome and should not be considered as a contraindication in this condition. This is the first reported case of corpus callosotomy in Rett syndrome.
Entities:
Keywords:
Drop attack; Endoscopic neurosurgery; Rett syndrome; Total corpus callosotomy
Authors: P Tinuper; A Cerullo; C Marini; P Avoni; A Rosati; R Riva; A Baruzzi; E Lugaresi Journal: J Neurol Neurosurg Psychiatry Date: 1998-02 Impact factor: 10.154
Authors: Daniel C Tarquinio; Wei Hou; Anne Berg; Walter E Kaufmann; Jane B Lane; Steven A Skinner; Kathleen J Motil; Jeffrey L Neul; Alan K Percy; Daniel G Glaze Journal: Brain Date: 2016-12-21 Impact factor: 13.501
Authors: A Mahmood; G Bibat; A-L Zhan; I Izbudak; L Farage; A Horska; S Mori; S Naidu Journal: AJNR Am J Neuroradiol Date: 2009-10-15 Impact factor: 3.825
Authors: Regina S Bower; Elaine Wirrell; Macaulay Nwojo; Nicholas M Wetjen; W Richard Marsh; Fredric B Meyer Journal: Neurosurgery Date: 2013-12 Impact factor: 4.654