Literature DB >> 28815209

Pathways to Genome-targeted Therapies in Serous Ovarian Cancer.

Joshua Axelrod1, Joe Delaney1.   

Abstract

Genome sequencing technologies and corresponding oncology publications have generated enormous publicly available datasets for many cancer types. While this has enabled new treatments, and in some limited cases lifetime management of the disease, the treatment options for serous ovarian cancer remain dismal. This review summarizes recent advances in our understanding of ovarian cancer, with a focus on heterogeneity, functional genomics, and actionable data.

Entities:  

Keywords:  genomics; heterogeneity; ovarian cancer; pathway analysis; targeted therapy

Year:  2017        PMID: 28815209      PMCID: PMC5555645     

Source DB:  PubMed          Journal:  J Nat Sci        ISSN: 2377-2700


  54 in total

1.  Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism.

Authors:  Yanyan Cai; Jonathan Crowther; Tibor Pastor; Layka Abbasi Asbagh; Maria Francesca Baietti; Magdalena De Troyer; Iria Vazquez; Ali Talebi; Fabrizio Renzi; Jonas Dehairs; Johannes V Swinnen; Anna A Sablina
Journal:  Cancer Cell       Date:  2016-05-09       Impact factor: 31.743

2.  Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.

Authors:  Mark A Eckert; Shawn Pan; Kyle M Hernandez; Rachel M Loth; Jorge Andrade; Samuel L Volchenboum; Pieter Faber; Anthony Montag; Ricardo Lastra; Marcus E Peter; S Diane Yamada; Ernst Lengyel
Journal:  Cancer Discov       Date:  2016-10-07       Impact factor: 39.397

3.  Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action.

Authors:  Yves Pommier; Mark J O'Connor; Johann de Bono
Journal:  Sci Transl Med       Date:  2016-10-26       Impact factor: 17.956

Review 4.  Precision oncology: origins, optimism, and potential.

Authors:  Vinay Prasad; Tito Fojo; Michael Brada
Journal:  Lancet Oncol       Date:  2016-02       Impact factor: 41.316

5.  Integrated genomic characterization of papillary thyroid carcinoma.

Authors: 
Journal:  Cell       Date:  2014-10-23       Impact factor: 41.582

6.  Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

Authors:  Iñigo Martincorena; Amit Roshan; Moritz Gerstung; Peter Ellis; Peter Van Loo; Stuart McLaren; David C Wedge; Anthony Fullam; Ludmil B Alexandrov; Jose M Tubio; Lucy Stebbings; Andrew Menzies; Sara Widaa; Michael R Stratton; Philip H Jones; Peter J Campbell
Journal:  Science       Date:  2015-05-22       Impact factor: 47.728

7.  Evolutionary dynamics of cancer in response to targeted combination therapy.

Authors:  Ivana Bozic; Johannes G Reiter; Benjamin Allen; Tibor Antal; Krishnendu Chatterjee; Preya Shah; Yo Sup Moon; Amin Yaqubie; Nicole Kelly; Dung T Le; Evan J Lipson; Paul B Chapman; Luis A Diaz; Bert Vogelstein; Martin A Nowak
Journal:  Elife       Date:  2013-06-25       Impact factor: 8.140

8.  Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

Authors:  Roland F Schwarz; Charlotte K Y Ng; Susanna L Cooke; Scott Newman; Jillian Temple; Anna M Piskorz; Davina Gale; Karen Sayal; Muhammed Murtaza; Peter J Baldwin; Nitzan Rosenfeld; Helena M Earl; Evis Sala; Mercedes Jimenez-Linan; Christine A Parkinson; Florian Markowetz; James D Brenton
Journal:  PLoS Med       Date:  2015-02-24       Impact factor: 11.069

9.  Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance.

Authors:  Anil Belur Nagaraj; Peronne Joseph; Olga Kovalenko; Sareena Singh; Amy Armstrong; Raymond Redline; Kimberly Resnick; Kristine Zanotti; Steven Waggoner; Analisa DiFeo
Journal:  Oncotarget       Date:  2015-09-15

10.  Mutational landscape and significance across 12 major cancer types.

Authors:  Cyriac Kandoth; Michael D McLellan; Fabio Vandin; Kai Ye; Beifang Niu; Charles Lu; Mingchao Xie; Qunyuan Zhang; Joshua F McMichael; Matthew A Wyczalkowski; Mark D M Leiserson; Christopher A Miller; John S Welch; Matthew J Walter; Michael C Wendl; Timothy J Ley; Richard K Wilson; Benjamin J Raphael; Li Ding
Journal:  Nature       Date:  2013-10-17       Impact factor: 49.962

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