Literature DB >> 28814892

Treatment of a traumatic atrophic depressed scar with hyaluronic acid fillers: a case report.

Syed Nazim Hussain1, Greg J Goodman2,3, Eqram Rahman4.   

Abstract

BACKGROUND: Hyaluronic acid filler has been documented in the treatment of atrophic depressed acne scars relatively frequently in the literature but rarely in chronic depressed traumatic atrophic facial scars.
METHODS: This case report discusses the use of hyaluronic acid fillers in the correction of a post-traumatic facial atrophic scar on the right cheek.
RESULTS: The right cheek scar was substantially corrected with one session of two different hyaluronic acids injected in a deep and superficial plane.
CONCLUSION: Relatively accurate, simple and effective correction of this atrophic traumatic scar may suggest that fillers are a suitable alternative to surgery for such scars.

Entities:  

Keywords:  facial scar; filler; hyaluronic acid; scar correction; scarring

Year:  2017        PMID: 28814892      PMCID: PMC5546592          DOI: 10.2147/CCID.S132626

Source DB:  PubMed          Journal:  Clin Cosmet Investig Dermatol        ISSN: 1178-7015


Introduction

Treating atrophic depressed scars with hyaluronic acid biodegradable dermal fillers has been shown to yield satisfactory results with high patient satisfaction and minimum risks but the literature predominantly confines the nonesthetic utilization of hyaluronic acid fillers to depressed acne scars.1–3 There have been a few cases reported in the literature where steroid-induced atrophic scars have been successfully treated with hyaluronic acid fillers;4,5 however, there is only a single case reported, where a depressed non-acne scar on patient’s forearm was successfully treated with hyaluronic acid filler.6 We present here an additional case of a chronic post-traumatic scar treated purely with hyaluronic acid without the use of subcision or other surgical procedure.

Case report

A 42-year-old female presented with a traumatic depressed scar of ~8×1 cm over the right cheek, extending from the lower eyelid to the nasolabial fold (Figure 1A). Historically, the scar originated 20 years prior to presentation as a result of a road traffic accident. This scar caused significant psychological distress to the patient and resulted in her seeking multiple consultations with plastic surgeons for surgical reconstruction. The patient was not keen on surgical scar revision and sought an alternative to this approach. After counseling and discussion about the likely outcome with dermal fillers, the patient decided to undertake correction with dermal fillers.
Figure 1

(A) Patient before scar correction with hyaluronic acid fillers. (B) Patient after 2 mL of hyaluronic acid filler.

Optimal correction was achieved by injecting a total of 2.0 mL hyaluronic acid filler with a flexible 24G blunt cannula. One milliliter of Juvederm Voluma XC (Allergan Inc Irvine Cal) was injected deeply into the scar tissue and 1.0 mL Juvederm Ultra XC (Allergan Inc, Irvine Cal) was injected more superficially into wrinkled atrophic scar tissue. Treatment proved safe and effective for the correction of the scar, as immediately after the procedure the correction achieved was visible and satisfactory (Figure 1B). The scar was filled up to the level of normal adjacent skin with no erythema, pain/or tenderness, lumps/bumps, swelling and bruises or bleeding. The face appeared more symmetrical while comparing with the left side (Figure 1B). A follow-up review conducted at 2 weeks and long-term clinically meaningful results were still apparent at 6 months following the procedure. There were no complications. The patient has provided written informed consent to have the case details and any accompanying images published.

Discussion

Atrophic scarring may be improved by many methods. These include re-excision of the scar, which was not favored in this case by the patient. Subcision is an elegant procedure for post-acne, post-disease and post-trauma scarring7 but usually requires more than one treatment8 and is relatively inaccurate relying on the individual patient’s wound-healing ability. Additions to this technique have been made such as suction techniques that may add to its efficacy.9 However, it remains a significant procedure for a patient with a scar as long as this case report. Fat transfer is also an alternative here10 but requires a procedure to extract and prepare the fat and although a very useful procedure may be variable in its results.11 Ablative and fractional energy-based devices may also be considered12 but given the volume deficit here it is unlikely that these would be efficacious in this case. Fillers are accurate in their placement and are a relatively elegant approach to volume-related scarring but, oddly, have been seldom reported for this purpose.1,13 The versatility and accuracy would suggest that these agents are ideally situated to serve the purpose of adding volume to atrophic scarring of all types. Hyaluronic acid, in particular, is well positioned to treat this condition. As well as its reversibility,14 accuracy of attainable correction and variable products with different lifting and spreading abilities, it is a relatively atraumatic and easily understandable procedure to the patient. The end result, behavior and the clinical outcome of hyaluronic acid filler depend on parameters of the filler such as gel hardness (G′) that determines the stiffness of gel, the concentration of hyaluronic acid that establishes its stability and durability, particle size and degree of crosslinking.15 This case demonstrates the use of two types of crosslinked hyaluronic acid, taking advantage of the slightly different characteristics to allow an accurate two-layer correction of this difficult scar. Specifically, the deep underpinning layer was placed with Juvederm Voluma XC, a biodegradable hyaluronic acid dermal filler. This is a mixture of low- and high-molecular weight hyaluronic acid at a concentration of 20 mg/mL containing 0.3% lidocaine. It has proven efficacy and longevity of 24 months.16 In this case, the 27-gauge needle supplied in the pack was not used but instead the hyaluronic acid positioned using a flexible blunt 24-gauge cannula. Juvederm Ultra XC has an extended longevity of 12 months17 and may achieve longer durations with repeated injection18 and is more a filler when more superficial placement and support is required. This was used in a more superficial level here to maximize accuracy of correction of the scar with the 30-gauge needle incorporated in the Juvederm Ultra XC package. Although major utilization of hyaluronic acid fillers has been in filling of lines, fighting the effects of aging, face sculpting and volumization,19–21 this case further strengthens the additional benefits of hyaluronic acid fillers in treatment of traumatic atrophic scars with no major short-term or late complications. Utilizing the different gel characteristics injected at different levels of skin, deep to superficial resulted in restoration of a natural facial shape with much improved esthetic results in this patient. Juvederm Voluma XC is recommended for deep subcutaneous injections and Juvederm Ultra XC for more superficial planes.16

Conclusion

Atrophic depressed facial scars can be effectively treated with hyaluronic acid fillers with esthetically satisfactory clinical outcome with a low risk or complications. This case reports that appropriate selection of hyaluronic acid fillers with varying characteristics is a feasible option for the treatment of traumatic atrophic depressed scars.
  21 in total

1.  A Combination Approach to Perioral Rejuvenation.

Authors:  Rebecca S Danhof; Joel L Cohen
Journal:  J Drugs Dermatol       Date:  2016-01       Impact factor: 2.114

2.  Therapeutic undermining of scars (Subcision).

Authors:  G J Goodman
Journal:  Australas J Dermatol       Date:  2001-05       Impact factor: 2.875

Review 3.  Acne Scar Treatment: A Multimodality Approach Tailored to Scar Type.

Authors:  Lisa A Zaleski-Larsen; Sabrina G Fabi; Timothy McGraw; Mark Taylor
Journal:  Dermatol Surg       Date:  2016-05       Impact factor: 3.398

4.  Midface and perioral volume restoration: a conversation between the US and Italy.

Authors:  Erin Gilbert; Lucia Calvisi
Journal:  J Drugs Dermatol       Date:  2014-01       Impact factor: 2.114

5.  Hyaluronic acid filler for a depressed scar.

Authors:  Farhan Khan; Kristen Richards; Rashid M Rashid
Journal:  Dermatol Online J       Date:  2012-05-15

6.  Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers.

Authors:  Stacy R Smith; Derek Jones; Jane A Thomas; Diane K Murphy; Frederick C Beddingfield
Journal:  Arch Dermatol Res       Date:  2010-10-09       Impact factor: 3.017

7.  Fractional CO(2) laser treatment vs autologous fat transfer in the treatment of acne scars: a comparative study.

Authors:  Omar A Azzam; Ahmed T Atta; Rehab M Sobhi; Pakinam I N Mostafa
Journal:  J Drugs Dermatol       Date:  2013-01       Impact factor: 2.114

8.  Juvéderm injectable gel: a multicenter, double-blind, randomized study of safety and effectiveness.

Authors:  Mark A Pinsky; Jane A Thomas; Diane K Murphy; Patricia S Walker
Journal:  Aesthet Surg J       Date:  2008 Jan-Feb       Impact factor: 4.283

9.  The modified tower vertical filler technique for the treatment of post-acne scarring.

Authors:  Greg J Goodman; Amanda Van Den Broek
Journal:  Australas J Dermatol       Date:  2015-09-07       Impact factor: 2.875

Review 10.  Managing Complications of Fillers: Rare and Not-So-Rare.

Authors:  Eckart Haneke
Journal:  J Cutan Aesthet Surg       Date:  2015 Oct-Dec
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  4 in total

1.  Human Novel MicroRNA Seq-915_x4024 in Keratinocytes Contributes to Skin Regeneration by Suppressing Scar Formation.

Authors:  Feng Zhao; Hongxin Lang; Zhe Wang; Tao Zhang; Dianbao Zhang; Rui Wang; Xuewen Lin; Xiaoyu Liu; Ping Shi; Xining Pang
Journal:  Mol Ther Nucleic Acids       Date:  2019-01-10       Impact factor: 8.886

2.  Effectiveness of CO2 laser therapy in treating acne depressed scar: A protocol of systematic review.

Authors:  Huan Zang; Ya-Nan Xu
Journal:  Medicine (Baltimore)       Date:  2021-01-22       Impact factor: 1.889

Review 3.  A Comprehensive Review of Non-Energy-Based Treatments for Atrophic Acne Scarring.

Authors:  Curtis Tam; Jeffrey Khong; Kevin Tam; Ruslan Vasilev; Wesley Wu; Salar Hazany
Journal:  Clin Cosmet Investig Dermatol       Date:  2022-03-14

4.  Effectiveness and Safety Analysis of Plasma Beam in the Treatment of Facial Depressed Scars.

Authors:  Juan Li; Xia Zhang
Journal:  Emerg Med Int       Date:  2022-08-25       Impact factor: 1.621

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