Literature DB >> 28813157

Palladium-Catalyzed Sequential Nucleophilic Addition/Oxidative Annulation of Bromoalkynes with Benzoic Acids To Construct Functionalized Isocoumarins.

Guangbin Jiang1, JianXiao Li1, Chuanle Zhu1, Wanqing Wu1, Huanfeng Jiang1.   

Abstract

An efficient and robust protocol for the preparation of 3-substituted isocoumarins via palladium-catalyzed nucleophilic addition/oxidative annulation of bromoalkynes with benzoic acids has been developed. Remarkably, preliminary mechanistic studies indicated that the transformation might proceed via a stereo- and regioselective nucleophilic addition and C-H functionalization procedure.

Entities:  

Year:  2017        PMID： 28813157     DOI： 10.1021/acs.orglett.7b01919

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide.

Authors:  Ming Yao; Jingjing Zhang; Sen Yang; Hangxing Xiong; Li Li; E Liu; Hong Shi
Journal:  RSC Adv       Date:  2020-01-23       Impact factor: 4.036

2.  Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination.

Authors:  Eric Tan; Andrey I Konovalov; Gabriela A Fernández; Ruth Dorel; Antonio M Echavarren
Journal:  Org Lett       Date:  2017-10-04       Impact factor: 6.005

3.  Exploring the Mechanism of the Palladium-Catalyzed 3-Butene-2-ol Amination Reaction: A DFT Study.

Authors:  Lingshan Lyu; Wei Feng; Siwei Yang; Huiling Liu; Xuri Huang
Journal:  Front Chem       Date:  2020-02-21       Impact factor: 5.221
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.