| Literature DB >> 28813102 |
Mauricio M Victor1,2, Jorge M David1,2, Maria C K Sakukuma1,2, Letícia V Costa-Lotufo3,4, Andrea F Moura3, Ana J Araújo3,5.
Abstract
Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.Entities:
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Year: 2017 PMID： 28813102 DOI： 10.1590/0001-3765201720160780
Source DB: PubMed Journal: An Acad Bras Cienc ISSN： 0001-3765 Impact factor: 1.753