Literature DB >> 28812433

Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease.

YouJin Lee1, Conrad C Weihl1.   

Abstract

Macroautophagy/autophagy can be a selective degradative process via the utilization of various autophagic receptor proteins. Autophagic receptors selectively recognize ubiquitinated cargoes and deliver them to phagophores, the precursors to autophagosomes, for their degradation. For example, SQSTM1/p62 directly binds to ubiquitinated protein aggregates via its UBA domain and sequesters them into inclusion bodies via its PB1 domain. SQSTM1also interacts with phagophores via its LC3-interacting (LIR) motif. However, a regulatory mechanism for autophagic receptors is not yet understood.

Entities:  

Keywords:  Keap1-Cullin3-Nrf2 pathway; autophagy; neurodegenerative diseases; p62/SQSTM1; protein aggregates; ubiquitination

Mesh：

Substances：

Year:  2017        PMID： 28812433      PMCID： PMC5612413          DOI： 10.1080/15548627.2017.1339845

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  23 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-03       Impact factor: 11.205

2.  Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection.

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Review 3.  Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets.

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Review 4.  Autophagy in Parkinson's Disease.

Authors:  Xu Hou; Jens O Watzlawik; Fabienne C Fiesel; Wolfdieter Springer
Journal:  J Mol Biol       Date:  2020-02-13       Impact factor: 5.469

5.  DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1.

Authors:  Hao Zhang; Yanqiu Zhang; Xiaoyun Zhu; Chen Chen; Chao Zhang; Yuanzheng Xia; Yucheng Zhao; Ourania Andrisani; Lingyi Kong
Journal:  Hepatology       Date:  2019-02-08       Impact factor: 17.425

Review 6.  The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers.

Authors:  Shunbin Ning; Ling Wang
Journal:  Curr Cancer Drug Targets       Date:  2019       Impact factor: 3.428

Review 7.  Nrf2 as a potential target for Parkinson's disease therapy.

Authors:  Yingcai Niu; Jing Zhang; Miaoxian Dong
Journal:  J Mol Med (Berl)       Date:  2021-04-12       Impact factor: 4.599

8.  The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2.

Authors:  Dipankar Ash; Varadarajan Sudhahar; Seock-Won Youn; Mustafa Nazir Okur; Archita Das; John P O'Bryan; Maggie McMenamin; Yali Hou; Jack H Kaplan; Tohru Fukai; Masuko Ushio-Fukai
Journal:  Nat Commun       Date:  2021-05-25       Impact factor: 17.694

9.  High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol.

Authors:  Jana Deitersen; Lena Berning; Fabian Stuhldreier; Sara Ceccacci; David Schlütermann; Annabelle Friedrich; Wenxian Wu; Yadong Sun; Philip Böhler; Niklas Berleth; María José Mendiburo; Sabine Seggewiß; Ruchika Anand; Andreas S Reichert; Maria Chiara Monti; Peter Proksch; Björn Stork
Journal:  Cell Death Dis       Date:  2021-05-31       Impact factor: 8.469

Review 10.  Autophagy in liver diseases: A review.

Authors:  Hui Qian; Xiaojuan Chao; Jessica Williams; Sam Fulte; Tiangang Li; Ling Yang; Wen-Xing Ding
Journal:  Mol Aspects Med       Date:  2021-06-11
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