| Literature DB >> 28812212 |
Fabio Bustamante1, Vitor Ottoboni Brunaldi2, Wanderley Marques Bernardo1, Diogo Turiani H de Moura1, Eduardo Turiani H de Moura1, Manoel Galvão3, Marco Aurélio Santo4, Eduardo Guimarães H de Moura1.
Abstract
The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records. Six studies fulfilled eligibility criteria. After critical appraisal, two articles were excluded and we meta-analyzed the remainder. The mean difference for absolute weight loss and BMI reduction were 0.12 [CI 95%, - 1.14, 1.38] and - 0.06 [95% CI, - 0.92, 0.81], respectively. Therefore, we concluded that treatment of obesity with BTA is not effective.Entities:
Keywords: Botulinum toxins; Endoscopy; Gastric emptying; Meta-analysis; Obesity; Systematic review
Mesh：
Substances：
Year: 2017 PMID： 28812212 DOI： 10.1007/s11695-017-2857-5
Source DB: PubMed Journal: Obes Surg ISSN： 0960-8923 Impact factor: 4.129