| Literature DB >> 2881134 |
G Starkebaum, T P Loughran, V S Kalyanaraman, M E Kadin, P G Kidd, J W Singer, F W Ruscetti.
Abstract
To investigate the possibility that the recently recognised syndrome, leukaemia of large granular lymphocytes, could be associated with human T-cell leukaemia/lymphoma virus type I (HTLV-I), sera from 12 patients with this type of leukaemia were tested by the use of western-blot techniques for IgG antibodies to proteins related to human T-cell leukaemia/lymphoma virus type I (HTLV-I). Sera from 6 patients, including 2 patients with rheumatoid arthritis, reacted with p19 or p24 retroviral proteins or both. In contrast, no sample from 32 patients with uncomplicated rheumatoid arthritis, 27 with Felty's syndrome, 11 with other connective tissue disorders, or 21 normal individuals reacted with HTLV-I. The results suggest that leukaemia of large granular lymphocytes may be associated with a retrovirus related to HTLV-I.Entities:
Mesh：
Substances：
Year: 1987 PMID： 2881134 DOI： 10.1016/s0140-6736(87)90236-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321