| Literature DB >> 28811077 |
Uzma Shahab1, Mohd Kaleem Ahmad2, Abbas Ali Mahdi2, Mohd Waseem3, Binish Arif4, Saheem Ahmad5.
Abstract
The receptor for advanced glycation end products (RAGEs) was first illustrated in the year 1992. RAGE is a single-transmembrane and multi-ligand component of the immunoglobulin protein super family. The engagement of RAGE turns out to an establishment of numerous intracellular signalling mechanisms resulting in the progression and perpetuation of many types of cancer including, the pancreatic cancer. The present review primarily focuses on the multi-ligand activation of RAGEs leading to the downstream signalling cascade activation. The kick start of the RAGEs activation leads to the several anomalies and includes multiple types of cancers. The RAGE expression correlates well with the survival of pancreatic cancer cells leading to the myeloid response. RAGEs assist in the tumourogenesis which enhance and thrive to its fullest in the stressed tumour microenvironment. An improved perceptive of its involvement in pancreatic cancer may offer novel targets for tumour supervision and risk measurement.Entities:
Keywords: Hypoxia; Pancreatic cancer; RAGE; Signalling; Tumourigenesis
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Year: 2017 PMID： 28811077 DOI： 10.1016/j.semcancer.2017.07.010
Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707