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Literature DB >> 28810672

Cardiomyocyte renewal in the human heart: insights from the fall-out.

Eniko Lázár¹, Hesham A Sadek^2,3, Olaf Bergmann^1,4.

Abstract

The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies. Published on behalf of the European Society of Cardiology. All rights reserved.

Entities: Chemical Species

Keywords: Cardiomyocyte proliferation; Dynamics of renewal; Retrospective radiocarbon dating

Mesh：

Year: 2017 PMID： 28810672 PMCID： PMC5837331 DOI： 10.1093/eurheartj/ehx343

Source DB: PubMed Journal: Eur Heart J ISSN： 0195-668X Impact factor: 29.983

100 in total

1. Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment.

Authors: Chang-Hwan Yoon; Masamichi Koyanagi; Kazuma Iekushi; Florian Seeger; Carmen Urbich; Andreas M Zeiher; Stefanie Dimmeler
Journal: Circulation Date: 2010-04-26 Impact factor: 29.690

2. Age Determination by Radiocarbon Content: World-Wide Assay of Natural Radiocarbon.

Authors: W F Libby; E C Anderson; J R Arnold
Journal: Science Date: 1949-03-04 Impact factor: 47.728

Review 3. Towards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation.

Authors: David C Zebrowski; Robert Becker; Felix B Engel
Journal: Am J Physiol Heart Circ Physiol Date: 2016-02-26 Impact factor: 4.733

4. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.

Authors: Volker Schächinger; Sandra Erbs; Albrecht Elsässer; Werner Haberbosch; Rainer Hambrecht; Hans Hölschermann; Jiangtao Yu; Roberto Corti; Detlef G Mathey; Christian W Hamm; Tim Süselbeck; Birgit Assmus; Torsten Tonn; Stefanie Dimmeler; Andreas M Zeiher
Journal: N Engl J Med Date: 2006-09-21 Impact factor: 91.245

5. Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes.

Authors: Scott D Shapiro; Amaresh K Ranjan; Yoshiaki Kawase; Richard K Cheng; Rina J Kara; Romit Bhattacharya; Gabriela Guzman-Martinez; Javier Sanz; Mario J Garcia; Hina W Chaudhry
Journal: Sci Transl Med Date: 2014-02-19 Impact factor: 17.956

6. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.

Authors: Chris Jopling; Eduard Sleep; Marina Raya; Mercè Martí; Angel Raya; Juan Carlos Izpisúa Belmonte
Journal: Nature Date: 2010-03-25 Impact factor: 49.962

7. Cardiovascular disease in Europe--epidemiological update 2015.

Authors: Nick Townsend; Melanie Nichols; Peter Scarborough; Mike Rayner
Journal: Eur Heart J Date: 2015-08-25 Impact factor: 29.983

8. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium.

Authors: Hina W Chaudhry; Nurin H Dashoush; Haiying Tang; Ling Zhang; Xiangyuan Wang; Ed X Wu; Debra J Wolgemuth
Journal: J Biol Chem Date: 2004-05-24 Impact factor: 5.157

9. Cardiomyocyte proliferation contributes to heart growth in young humans.

Authors: Mariya Mollova; Kevin Bersell; Stuart Walsh; Jainy Savla; Lala Tanmoy Das; Shin-Young Park; Leslie E Silberstein; Cristobal G Dos Remedios; Dionne Graham; Steven Colan; Bernhard Kühn
Journal: Proc Natl Acad Sci U S A Date: 2013-01-09 Impact factor: 11.205

10. Systematic selection of small molecules to promote differentiation of embryonic stem cells and experimental validation for generating cardiomyocytes.

Authors: Y KalantarMotamedi; M Peymani; H Baharvand; M H Nasr-Esfahani; A Bender
Journal: Cell Death Discov Date: 2016-02-08

43 in total

1. Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI).

Authors: Roberto Alvarez; Bingyan J Wang; Pearl J Quijada; Daniele Avitabile; Thi Ho; Maya Shaitrit; Monica Chavarria; Fareheh Firouzi; David Ebeid; Megan M Monsanto; Natalie Navarrete; Maryam Moshref; Sailay Siddiqi; Kathleen M Broughton; Barbara A Bailey; Natalie A Gude; Mark A Sussman
Journal: J Mol Cell Cardiol Date: 2018-12-18 Impact factor: 5.000

Cardiomyocyte renewal in the human heart: insights from the fall-out.

1. Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment.

2. Age Determination by Radiocarbon Content: World-Wide Assay of Natural Radiocarbon.

Review 3. Towards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation.

4. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.

5. Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes.

6. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.

7. Cardiovascular disease in Europe--epidemiological update 2015.

8. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium.

9. Cardiomyocyte proliferation contributes to heart growth in young humans.

10. Systematic selection of small molecules to promote differentiation of embryonic stem cells and experimental validation for generating cardiomyocytes.

1. Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI).

2. Differential DNA Methylation in Placenta Associated With Maternal Blood Pressure During Pregnancy.

Review 3. Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation for Heart Disease Treatment.

4. A step closer to improving cardiac homing of adipose-derived mesenchymal stem cells.

Review 5. Copper promotion of myocardial regeneration.

Review 6. The heart of the neural crest: cardiac neural crest cells in development and regeneration.

Review 7. Exercise and cardiac health: physiological and molecular insights.

Review 8. Cardiac regeneration in 2017: Novel paradigms in the fight against heart failure.

Review 9. Cardiac regenerative therapy: Many paths to repair.

Review 10. Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations.