Literature DB >> 2880984

The effect of polycarbophil on the gastric emptying of pellets.

R Khosla, S S Davis.   

Abstract

The influence of the putative bioadhesive, polycarbophil, on the gastric emptying of a pellet formulation, has been investigated in three fasted subjects. The pellets were radiolabelled with technetium-99m. Gastric emptying was measured using the technique of gamma scintigraphy. The pellets emptied from the stomach rapidly and in an exponential manner. Polycarbophil did not retard the gastric emptying of the pellets.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2880984     DOI： 10.1111/j.2042-7158.1987.tb07161.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  8 in total

Review 1.  Gamma scintigraphy in the evaluation of pharmaceutical dosage forms.

Authors:  S S Davis; J G Hardy; S P Newman; I R Wilding
Journal:  Eur J Nucl Med       Date:  1992

2.  Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.

Authors:  A J Coupe; S S Davis; I R Wilding
Journal:  Pharm Res       Date:  1991-03       Impact factor: 4.200

Review 3.  From sticky stuff to sweet receptors--achievements, limits and novel approaches to bioadhesion.

Authors:  C M Lehr
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1996 Apr-Jun       Impact factor: 2.441

4.  In vivo and in vitro characterization of novel microparticulates based on hyaluronan and chitosan hydroglutamate.

Authors:  S T Lim; B Forbes; G P Martin; M B Brown
Journal:  AAPS PharmSciTech       Date:  2001-10-17       Impact factor: 3.246

5.  Effect of a hydrophobic phospholipid lining of the gastric mucosa in bioadhesion.

Authors:  Jae Han Park; Joseph R Robinson
Journal:  Pharm Res       Date:  2007-09-06       Impact factor: 4.200

6.  Gastrointestinal transit of nondisintegrating, nonerodible oral dosage forms in pigs.

Authors:  M Hossain; W Abramowitz; B J Watrous; G J Szpunar; J W Ayres
Journal:  Pharm Res       Date:  1990-11       Impact factor: 4.200

7.  In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative.

Authors:  Y Akiyama; N Nagahara; T Kashihara; S Hirai; H Toguchi
Journal:  Pharm Res       Date:  1995-03       Impact factor: 4.200

8.  Gastric emptying of pellets under fasting conditions: a mathematical model.

Authors:  Igor Locatelli; Ales Mrhar; Marija Bogataj
Journal:  Pharm Res       Date:  2009-04-01       Impact factor: 4.200
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.