Literature DB >> 2880977

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age.

W A Al-Turk, S J Stohs, F H el-Rashidy, S Othman.   

Abstract

The levels of glutathione (GSH) and the activities of glutathione S-transferases (GST) and glutathione reductase (GSR) in human erythrocytes and lymphocytes were determined in three age groups (5-12, 25-40, 65-83 years). The levels of GSH in lymphocytes increased with age, however, its levels in erythrocytes reached a maximum in the middle age group. The activity of GST in erythrocytes and lymphocytes changed as a function of age in a pattern similar to the changes found for GSH levels. GSR activity increased from young to middle age in both erythrocytes and lymphocytes, but decreased again in the old age group.

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Year:  1987        PMID: 2880977     DOI: 10.1111/j.2042-7158.1987.tb07154.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  5 in total

1.  Biological effect monitoring of occupational exposure to 1,3-dichloropropene: effects on liver and renal function and on glutathione conjugation.

Authors:  E J Brouwer; C T Evelo; A J Verplanke; R T van Welie; F A de Wolff
Journal:  Br J Ind Med       Date:  1991-03

2.  Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.

Authors:  Rajagopal V Sekhar; Sanjeet G Patel; Anuradha P Guthikonda; Marvin Reid; Ashok Balasubramanyam; George E Taffet; Farook Jahoor
Journal:  Am J Clin Nutr       Date:  2011-07-27       Impact factor: 7.045

3.  Dairy intake is associated with brain glutathione concentration in older adults.

Authors:  In-Young Choi; Phil Lee; Douglas R Denney; Kendra Spaeth; Olivia Nast; Lauren Ptomey; Alexandra K Roth; Jo Ann Lierman; Debra K Sullivan
Journal:  Am J Clin Nutr       Date:  2014-12-10       Impact factor: 7.045

4.  Glycation (non-enzymic glycosylation) inactivates glutathione reductase.

Authors:  R Blakytny; J J Harding
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

5.  Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome.

Authors:  Kathryn Hollowood; Stepan Melnyk; Oleksandra Pavliv; Teresa Evans; Ashley Sides; Rebecca J Schmidt; Irva Hertz-Picciotto; William Elms; Elizabeth Guerrero; Uwe Kruger; Juergen Hahn; S Jill James
Journal:  Res Autism Spectr Disord       Date:  2018-09-19
  5 in total

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