Literature DB >> 28807825

USP3 stabilizes p53 protein through its deubiquitinase activity.

Song Fu1, Shize Shao1, Longqiang Wang1, Haijun Liu1, Haitao Hou1, Yanan Wang1, Huan Wang1, Xiangpeng Huang1, Renhua Lv2.   

Abstract

p53 is the guardian of the genome integrity and the degradation of p53 protein is mediated by MDM2. Here we report that USP3 interacts with p53 and regulates p53 stability. Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. These findings suggest that USP3 is an important regulator of p53 and regulates normal cell transformation.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cell proliferation; Cell transformation; Deubiquitination; USP3; p53

Mesh：

Substances：

Year:  2017        PMID： 28807825     DOI： 10.1016/j.bbrc.2017.08.036

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5.

Authors:  Yingying Wu; Junying Qin; Fubing Li; Chuanyu Yang; Zhen Li; Zhongmei Zhou; Hailin Zhang; Yunxi Li; Xinye Wang; Rong Liu; Qian Tao; Wenlin Chen; Ceshi Chen
Journal:  J Biol Chem       Date:  2019-10-17       Impact factor: 5.157

Review 2.  HOPS and p53: thick as thieves in life and death.

Authors:  Maria Agnese Della-Fazia; Marilena Castelli; Danilo Piobbico; Stefania Pieroni; Giuseppe Servillo
Journal:  Cell Cycle       Date:  2020-10-28       Impact factor: 4.534

3.  Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer.

Authors:  Xiaosheng Wu; Mengwei Liu; Huiqiong Zhu; Jing Wang; Weiyu Dai; Jiaying Li; Danping Zhu; Weimei Tang; Yizhi Xiao; Jianjiao Lin; Wenjing Zhang; Yong Sun; Yi Zhang; Yaying Chen; Guoxin Li; Aimin Li; Li Xiang; Side Liu; Jide Wang
Journal:  J Exp Clin Cancer Res       Date:  2019-06-24

4.  p53 modifications: exquisite decorations of the powerful guardian.

Authors:  Yanqing Liu; Omid Tavana; Wei Gu
Journal:  J Mol Cell Biol       Date:  2019-07-19       Impact factor: 6.216

5.  An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability.

Authors:  Zsuzsanna Nagy; Janith A Seneviratne; Maxwell Kanikevich; William Chang; Chelsea Mayoh; Pooja Venkat; Yanhua Du; Cizhong Jiang; Alice Salib; Jessica Koach; Daniel R Carter; Rituparna Mittra; Tao Liu; Michael W Parker; Belamy B Cheung; Glenn M Marshall
Journal:  Nat Commun       Date:  2021-03-25       Impact factor: 14.919

Review 6.  Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins.

Authors:  Sang-Soo Park; Kwang-Hyun Baek
Journal:  Int J Mol Sci       Date:  2022-01-03       Impact factor: 5.923

7.  Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma.

Authors:  Ke Shi; Jin Zhong Zhang; Liang Yang; Ning-Ning Li; Ying Yue; Xiu-Hong Du; Xiu-Zhi Zhang; Yu Cheng Lu; Dan Guo
Journal:  BMC Cancer       Date:  2021-11-10       Impact factor: 4.430

8.  Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.

Authors:  Chia-Lang Fang; Chih-Chan Lin; Han-Kun Chen; You-Cheng Hseu; Shih-Ting Hung; Ding-Ping Sun; Yih-Huei Uen; Kai-Yuan Lin
Journal:  Cancer Sci       Date:  2018-09-21       Impact factor: 6.716
  8 in total

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