Literature DB >> 28807400

IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258.

Louise T Cerdeira1, Marcos P V Cunha2, Gabriela R Francisco3, Maria Fernanda C Bueno3, Bruna F Araujo4, Rosineide M Ribas4, Paulo P Gontijo-Filho4, Terezinha Knöbl2, Doroti de Oliveira Garcia3, Nilton Lincopan5.   

Abstract

IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most blaKPC- and blaNDM-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-blaKPC-2-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Brazil; CC258; Carbapenemase; IncX3; KPC-2; Klebsiella pneumoniae

Mesh：

Substances：

Year:  2017        PMID： 28807400     DOI： 10.1016/j.diagmicrobio.2017.06.022

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  7 in total

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Authors:  Willames M B S Martins; Marisa F Nicolas; Yang Yu; Mei Li; Priscila Dantas; Kirsty Sands; Edward Portal; Luiz G P Almeida; Ana Tereza R Vasconcelos; Eduardo A Medeiros; Mark A Toleman; Timothy R Walsh; Ana C Gales; Diego O Andrey
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