Literature DB >> 2880731

Neurophysiological effects of buspirone and isapirone in the hippocampus: comparison with 5-hydroxytryptamine.

M J Rowan, R Anwyl.   

Abstract

The neurophysiological effects of two novel anxiolytic compounds, buspirone and isapirone (TVX Q 7821), were compared with those of 5-hydroxytryptamine (5-HT) on the population spike in the CA1 region of the rat hippocampal slice. Micromolar concentrations of the two drugs mimicked the inhibitory effect of 5-HT but unlike 5-HT they did not produce any significant excitation. In slices in which 5-HT was purely excitatory, there was a marked reduction in the inhibitory response to these agents. The effect of isapirone was antagonised by spiperone. These results suggest that buspirone and isapirone are agonists for 5-HT1A receptors in the hippocampus.

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Year:  1986        PMID： 2880731     DOI： 10.1016/0014-2999(86)90017-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  Buspirone impairment of performance of passive avoidance and spatial learning tasks in the rat.

Authors:  M J Rowan; W K Cullen; B Moulton
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

2.  Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors?

Authors:  J Maj; E Chojnacka-Wójcik; A Kłodzińska; A Dereń; E Moryl
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

3.  Proceedings of the British Pharmacological Society. Ireland, 6th-8th July, 1988. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

4.  The influence of ipsapirone, a 5-HT1A agonist, on sleep patterns of healthy subjects.

Authors:  H S Driver; M J Flanigan; A J Bentley; H G Luus; C M Shapiro; D Mitchell
Journal:  Psychopharmacology (Berl)       Date:  1995-01       Impact factor: 4.530

5.  Use-dependent effects of acute and chronic treatment with imipramine and buspirone on excitatory synaptic transmission in the rat hippocampus in vivo.

Authors:  J J O'Connor; M J Rowan; R Anwyl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-08       Impact factor: 3.000

6.  Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus.

Authors:  R Andrade; R A Nicoll
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-07       Impact factor: 3.000

7.  Development of tolerance to anxiolytic effects of chlordiazepoxide in elevated plus-maze test and decrease of GABAA receptors.

Authors:  S Ishihara; M Hiramatsu; T Kameyama; T Nabeshima
Journal:  J Neural Transm Gen Sect       Date:  1993

8.  Actions of 5-HT1 ligands on excitatory synaptic transmission in the hippocampus of alert rats.

Authors:  J J O'Connor; M J Rowan; R Anwyl
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

Review 9.  5-HT1A receptor agonists: recent developments and controversial issues.

Authors:  J De Vry
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

10.  The guinea-pig ileum preparation as a model for 5-HT1A receptors: anomalous effects with RS-30199-193.

Authors:  C Small; C M Brown; W S Redfern; M Spedding
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739
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