Chad A Grotegut1, Lauren L Lewis1, Tracy A Manuck2, Terrence K Allen3, Andra H James1, Aurelien Seco4, Catherine Deneux-Tharaux4. 1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina. 2. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 3. Division of Women's Anesthesia, Department of Anesthesiology, Duke University, Durham, North Carolina. 4. Obstetrical, Perinatal, and Pediatric Epidemiology Research Team, Institut National de la Sante et de la Recherche Medicale (INSERM) UMR 1153, Centre for Epidemiology and Statistics Sorbonne Paris Cité DHU Risks in Pregnancy, Paris Descartes Université, Paris, France.
Abstract
OBJECTIVE: Total dose of oxytocin received during labor is an important variable in studies of human labor but is difficult to calculate. We sought to identify a surrogate measure for total dose of oxytocin received. STUDY DESIGN: For each subject receiving oxytocin during labor, the oxytocin total dose received in labor was calculated as the area under the curve. Maximal oxytocin infusion rate, total duration of oxytocin infusion, and the product of both, defined as the oxytocin product, were then each correlated with the total dose of oxytocin received using the Pearson's correlation coefficient. RESULTS: Oxytocin dosing data were available from 402 women at Duke and 6,907 women from Pithagore6. The two variables alone, or combined as the oxytocin product, demonstrated a high correlation with the oxytocin total dose (r > 0.7), with the oxytocin product demonstrating the highest (r > 0.9). This was true whether labor was induced or augmented and whether delivery was vaginal or cesarean. CONCLUSION: The oxytocin product, composed of two easily obtained variables, demonstrated a very high correlation with total oxytocin dose received in labor and represents a simple and accurate surrogate for total dose of oxytocin received during labor. The oxytocin product can be used in clinical studies in which oxytocin dose is an important variable. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: Total dose of oxytocin received during labor is an important variable in studies of humanlabor but is difficult to calculate. We sought to identify a surrogate measure for total dose of oxytocin received. STUDY DESIGN: For each subject receiving oxytocin during labor, the oxytocin total dose received in labor was calculated as the area under the curve. Maximal oxytocin infusion rate, total duration of oxytocin infusion, and the product of both, defined as the oxytocin product, were then each correlated with the total dose of oxytocin received using the Pearson's correlation coefficient. RESULTS:Oxytocin dosing data were available from 402 women at Duke and 6,907 women from Pithagore6. The two variables alone, or combined as the oxytocin product, demonstrated a high correlation with the oxytocin total dose (r > 0.7), with the oxytocin product demonstrating the highest (r > 0.9). This was true whether labor was induced or augmented and whether delivery was vaginal or cesarean. CONCLUSION: The oxytocin product, composed of two easily obtained variables, demonstrated a very high correlation with total oxytocin dose received in labor and represents a simple and accurate surrogate for total dose of oxytocin received during labor. The oxytocin product can be used in clinical studies in which oxytocin dose is an important variable. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: C Deneux-Tharaux; C Dupont; C Colin; M Rabilloud; S Touzet; J Lansac; T Harvey; V Tessier; C Chauleur; G Pennehouat; X Morin; M H Bouvier-Colle; R Rudigoz Journal: BJOG Date: 2010-06-24 Impact factor: 6.531
Authors: Chad A Grotegut; Liping Feng; Lan Mao; R Phillips Heine; Amy P Murtha; Howard A Rockman Journal: Am J Physiol Endocrinol Metab Date: 2010-12-07 Impact factor: 4.310
Authors: Joyce K R S Magalhaes; Jose C A Carvalho; Robert K Parkes; John Kingdom; Yong Li; Mrinalini Balki Journal: Reprod Sci Date: 2009-01-22 Impact factor: 3.060
Authors: Manasi Malik; Michael D Ward; Yingye Fang; Justin R Porter; Maxwell I Zimmerman; Thomas Koelblen; Michelle Roh; Antonina I Frolova; Thomas P Burris; Gregory R Bowman; Princess I Imoukhuede; Sarah K England Journal: ACS Pharmacol Transl Sci Date: 2021-09-08