Andrew J Degnan1, Chul Y Chung2, Amisha J Shah3. 1. Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States. Electronic address: degnana@email.chop.edu. 2. Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States. Electronic address: chungcy@upmc.edu. 3. Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Pediatric Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States. Electronic address: shaha3@upmc.edu.
Abstract
OBJECTIVE: Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection. SUBJECTS AND METHODS: Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers. RESULTS: Treated tumors demonstrated significantly greater ADC values compared to untreated tumors (p<0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment. CONCLUSIONS: Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.
OBJECTIVE: Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection. SUBJECTS AND METHODS: Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers. RESULTS: Treated tumors demonstrated significantly greater ADC values compared to untreated tumors (p<0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment. CONCLUSIONS: Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.
Authors: William Rogers; Sithin Thulasi Seetha; Turkey A G Refaee; Relinde I Y Lieverse; Renée W Y Granzier; Abdalla Ibrahim; Simon A Keek; Sebastian Sanduleanu; Sergey P Primakov; Manon P L Beuque; Damiënne Marcus; Alexander M A van der Wiel; Fadila Zerka; Cary J G Oberije; Janita E van Timmeren; Henry C Woodruff; Philippe Lambin Journal: Br J Radiol Date: 2020-02-26 Impact factor: 3.039
Authors: Lianne M Haveman; Andreas Ranft; Henk Vd Berg; Anne Smets; Jarmila Kruseova; Ruth Ladenstein; Benedicte Brichard; Michael Paulussen; Thomas Kuehne; Heribert Juergens; Stephanie Klco-Brosius; Uta Dirksen; Johannes H M Merks Journal: Cancer Med Date: 2019-02-21 Impact factor: 4.452