Literature DB >> 28804119

Artificial Intelligence, DNA Mimicry, and Human Health.

George B Stefano1,2, Richard M Kream1.   

Abstract

The molecular evolution of genomic DNA across diverse plant and animal phyla involved dynamic registrations of sequence modifications to maintain existential homeostasis to increasingly complex patterns of environmental stressors. As an essential corollary, driver effects of positive evolutionary pressure are hypothesized to effect concerted modifications of genomic DNA sequences to meet expanded platforms of regulatory controls for successful implementation of advanced physiological requirements. It is also clearly apparent that preservation of updated registries of advantageous modifications of genomic DNA sequences requires coordinate expansion of convergent cellular proofreading/error correction mechanisms that are encoded by reciprocally modified genomic DNA. Computational expansion of operationally defined DNA memory extends to coordinate modification of coding and previously under-emphasized noncoding regions that now appear to represent essential reservoirs of untapped genetic information amenable to evolutionary driven recruitment into the realm of biologically active domains. Additionally, expansion of DNA memory potential via chemical modification and activation of noncoding sequences is targeted to vertical augmentation and integration of an expanded cadre of transcriptional and epigenetic regulatory factors affecting linear coding of protein amino acid sequences within open reading frames.

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Mesh:

Year:  2017        PMID: 28804119      PMCID: PMC5566202          DOI: 10.12659/msm.906498

Source DB:  PubMed          Journal:  Med Sci Monit        ISSN: 1234-1010


  3 in total

Review 1.  Synthesizing biomolecule-based Boolean logic gates.

Authors:  Takafumi Miyamoto; Shiva Razavi; Robert DeRose; Takanari Inoue
Journal:  ACS Synth Biol       Date:  2013-02-15       Impact factor: 5.110

2.  Personalized- and one- medicine: bioinformatics foundation in health and its economic feasibility.

Authors:  George B Stefano; Richard M Kream
Journal:  Med Sci Monit       Date:  2015-01-15

3.  Biosensors: Enhancing the Natural Ability to Sense and Their Dependence on Bioinformatics.

Authors:  George B Stefano; Elmer A Fernandez
Journal:  Med Sci Monit       Date:  2017-06-28
  3 in total
  1 in total

1.  DNA MemoChip: Long-Term and High Capacity Information Storage and Select Retrieval.

Authors:  George B Stefano; Fuzhou Wang; Richard M Kream
Journal:  Med Sci Monit       Date:  2018-02-26
  1 in total

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