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Literature DB >> 2880382

Phenotypic characterization of 3H-thymidine incorporating cells in rheumatoid arthritis synovial membrane.

P Nykänen, V Bergroth, P Raunio, D Nordström, Y T Konttinen.

Abstract

Tritiated-thymidine incorporating cells in synovial tissue samples from ten patients with definite or classic rheumatoid arthritis (RA) were studied by combining two techniques. Tritiated-thymidine-labelled cells were seen in autoradiography and simultaneously the subtype of them was determined with immunoperoxidase staining using monoclonal antibodies. Tritiated-thymidine-labelled cells comprised 0.8 +/- 0.4% of all the inflammatory cells in RA synovial membrane. Of all 3H-thymidine-labelled cells 34 +/- 17% were positive for OKT8 and 19 +/- 8% for OKT4 monoclonal antibodies. OKM1-positive cells comprised 7 +/- 3% of all 3H-thymidine labelled cells, whereas only a few (3 +/- 4%) of them were positive for pan-B monoclonal antibody. This study emphasizes the importance of activated OKT8 lymphocytes in RA synovial membrane.

Entities: Chemical Disease Species

Mesh：

Substances：
Thymidine

Year: 1986 PMID： 2880382 DOI： 10.1007/bf00541318

Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631

17 in total

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11 in total

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Authors: Laurie S Davis
Journal: Am J Pathol Date: 2003-05 Impact factor: 4.307

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Authors: A Plenz; P Fritz; G König; W Laschner; J G Saal
Journal: Rheumatol Int Date: 1996 Impact factor: 2.631