Suman Arya1, Jigyasa Duhan2, Sanjay Tewari1, Pankaj Sangwan1, Veena Ghalaut3, Sameer Aggarwal4. 1. Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, India. 2. Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, India. Electronic address: prashitiduhan@rediffmail.com. 3. Department of Biochemistry, Post Graduate Institute of Medical Sciences, Rohtak, India. 4. Department of Medicine/Endocrinology, Post Graduate Institute of Medical Sciences, Rohtak, India.
Abstract
INTRODUCTION: The purpose of this prospective study was to compare the success of primary root canal treatment between type 2 diabetic and nondiabetic patients and to investigate the effect of periapical healing on glycated hemoglobin (HbA1c) in type 2 diabetic patients with apical periodontitis. METHODS: Sixty mandibular molars with necrotic pulps and apical radiolucency (size ≥ 2 mm × 2 mm) were included in the study. Based on the HbA1c levels, patients were divided into 2 groups: type 2 diabetic (HbA1c ≥6.5%) and nondiabetic (HbA1c <6.5%). Forty-six teeth were evaluated at the 12-month follow-up time period. The primary outcome measure was the change in apical bone density as determined by the periapical index. RESULTS: Both the diabetic and nondiabetic group depicted a significant reduction in the periapical score after endodontic treatment at the 12-month follow-up (P < .05). Significantly less periapical healing was observed in the diabetic group (43%) compared with the nondiabetic group (80%) at the 12-month follow-up (P < .05). HbA1c levels in the diabetic group increased at each follow-up after endodontic treatment. CONCLUSIONS: Diabetes mellitus may have a negative impact on the outcome of endodontic treatment in terms of periapical healing. Nonsurgical endodontic treatment did not improve HbA1c levels in patients with type 2 diabetes.
INTRODUCTION: The purpose of this prospective study was to compare the success of primary root canal treatment between type 2 diabetic and nondiabetic patients and to investigate the effect of periapical healing on glycated hemoglobin (HbA1c) in type 2 diabeticpatients with apical periodontitis. METHODS: Sixty mandibular molars with necrotic pulps and apical radiolucency (size ≥ 2 mm × 2 mm) were included in the study. Based on the HbA1c levels, patients were divided into 2 groups: type 2 diabetic (HbA1c ≥6.5%) and nondiabetic (HbA1c <6.5%). Forty-six teeth were evaluated at the 12-month follow-up time period. The primary outcome measure was the change in apical bone density as determined by the periapical index. RESULTS: Both the diabetic and nondiabetic group depicted a significant reduction in the periapical score after endodontic treatment at the 12-month follow-up (P < .05). Significantly less periapical healing was observed in the diabetic group (43%) compared with the nondiabetic group (80%) at the 12-month follow-up (P < .05). HbA1c levels in the diabetic group increased at each follow-up after endodontic treatment. CONCLUSIONS:Diabetes mellitus may have a negative impact on the outcome of endodontic treatment in terms of periapical healing. Nonsurgical endodontic treatment did not improve HbA1c levels in patients with type 2 diabetes.
Authors: Yandy Gonzalez Marrero; Yoshifumi Kobayashi; Mohammad Saqib Ihsan; Lisa A Pilch; Liyaa Chen; Shuying Jiang; Yi Ye; Daniel H Fine; Carla Y Falcon; Paul A Falcon; Craig S Hirschberg; Emi Shimizu Journal: J Endod Date: 2021-11-13 Impact factor: 4.171