Jeremy Cypen1, Tariq Ahmad2, Jeffrey M Testani2, Adam D DeVore3,4. 1. Department of Medicine, Duke University School of Medicine, Durham, NC, USA. 2. Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA. 3. Department of Medicine, Duke University School of Medicine, Durham, NC, USA. adam.devore@duke.edu. 4. Duke Clinical Research Institute, Duke University School of Medicine, 2400 Pratt Street, NP-8064, Durham, NC, 27705, USA. adam.devore@duke.edu.
Abstract
PURPOSE OF REVIEW: The use of biomarkers in heart failure (HF) is a rapidly changing field. The purpose of this review is to assess the current evidence of the use of biomarkers for risk stratification in patients with HF with preserved ejection fraction (HFpEF). RECENT FINDINGS: Despite differences in pathophysiology between HF with reduced ejection fraction and HFpEF, traditional HF biomarkers such as brain natriuretic peptide and troponin retain prognostic value in most HFpEF-specific populations. Biomarkers of key pathophysiologic components of HFpEF, such as myocardial fibrosis, remodeling, and systemic inflammation are also valuable prognostic markers. Further investigation into HF biomarkers may identify significant therapeutic targets for the treatment of HFpEF.
PURPOSE OF REVIEW: The use of biomarkers in heart failure (HF) is a rapidly changing field. The purpose of this review is to assess the current evidence of the use of biomarkers for risk stratification in patients with HF with preserved ejection fraction (HFpEF). RECENT FINDINGS: Despite differences in pathophysiology between HF with reduced ejection fraction and HFpEF, traditional HF biomarkers such as brain natriuretic peptide and troponin retain prognostic value in most HFpEF-specific populations. Biomarkers of key pathophysiologic components of HFpEF, such as myocardial fibrosis, remodeling, and systemic inflammation are also valuable prognostic markers. Further investigation into HF biomarkers may identify significant therapeutic targets for the treatment of HFpEF.
Authors: Clyde W Yancy; Mariell Jessup; Biykem Bozkurt; Javed Butler; Donald E Casey; Monica M Colvin; Mark H Drazner; Gerasimos Filippatos; Gregg C Fonarow; Michael M Givertz; Steven M Hollenberg; JoAnn Lindenfeld; Frederick A Masoudi; Patrick E McBride; Pamela N Peterson; Lynne Warner Stevenson; Cheryl Westlake Journal: Circulation Date: 2016-05-20 Impact factor: 29.690
Authors: Kevin Damman; Dirk J Van Veldhuisen; Gerjan Navis; Vishal S Vaidya; Tom D J Smilde; B Daan Westenbrink; Joseph V Bonventre; Adriaan A Voors; Hans L Hillege Journal: Heart Date: 2010-08 Impact factor: 5.994
Authors: Tibor Kempf; Stephan von Haehling; Timo Peter; Tim Allhoff; Mariantonietta Cicoira; Wolfram Doehner; Piotr Ponikowski; Gerasimos S Filippatos; Piotr Rozentryt; Helmut Drexler; Stefan D Anker; Kai C Wollert Journal: J Am Coll Cardiol Date: 2007-08-24 Impact factor: 24.094
Authors: Dirk J Lok; Ijsbrand T Klip; Adriaan A Voors; Sjoukje I Lok; Pieta W Bruggink-André de la Porte; Hans L Hillege; Tiny Jaarsma; Dirk J van Veldhuisen; Peter van der Meer Journal: Eur J Heart Fail Date: 2014-07-31 Impact factor: 15.534
Authors: A Rogier van der Velde; Lars Gullestad; Thor Ueland; Pål Aukrust; Yu Guo; Aram Adourian; Pieter Muntendam; Dirk J van Veldhuisen; Rudolf A de Boer Journal: Circ Heart Fail Date: 2013-02-08 Impact factor: 8.790
Authors: Rajalakshmi Santhanakrishnan; Jenny P C Chong; Tze P Ng; Lieng H Ling; David Sim; Kui Toh G Leong; Poh Shuan D Yeo; Hean Y Ong; Fazlur Jaufeerally; Raymond Wong; Ping Chai; Adrian F Low; Arthur Mark Richards; Carolyn S P Lam Journal: Eur J Heart Fail Date: 2012-08-05 Impact factor: 15.534
Authors: Rudolf A de Boer; Dirk J A Lok; Tiny Jaarsma; Peter van der Meer; Adriaan A Voors; Hans L Hillege; Dirk J van Veldhuisen Journal: Ann Med Date: 2010-12-28 Impact factor: 4.709
Authors: Kalyani Anil Boralkar; Yukari Kobayashi; Kegan J Moneghetti; Vedant S Pargaonkar; Mirela Tuzovic; Gomathi Krishnan; Matthew T Wheeler; Dipanjan Banerjee; Tatiana Kuznetsova; Benjamin D Horne; Kirk U Knowlton; Paul A Heidenreich; Francois Haddad Journal: Open Heart Date: 2019-05-21
Authors: Olusola A Orimoloye; Swetha Kambhampati; Albert J Hicks; Mahmoud Al Rifai; Michael G Silverman; Seamus Whelton; Waqas Qureshi; Jonathan K Ehrman; Steven J Keteyian; Clinton A Brawner; Zeina Dardari; Mouaz H Al-Mallah; Michael J Blaha Journal: Arch Med Sci Date: 2019-03-04 Impact factor: 3.318
Authors: Barry Greenberg; Eric D Peterson; Jeffrey S Berger; François Laliberté; Qi Zhao; Guillaume Germain; Dominique Lejeune; Jennifer W Wu; Patrick Lefebvre; Gregg C Fonarow Journal: Clin Cardiol Date: 2019-01-07 Impact factor: 2.882
Authors: Selina Hein; Jennifer Furkel; Maximilian Knoll; Fabian Aus dem Siepen; Stefan Schönland; Ute Hegenbart; Hugo A Katus; Arnt V Kristen; Mathias H Konstandin Journal: Clin Res Cardiol Date: 2021-01-22 Impact factor: 5.460