Literature DB >> 2880322

2-Oxo-[14C]glutarate is taken up by glutamatergic nerve terminals in the rat striatum.

C J Carter, M Savasta, D Fage, B Scatton.   

Abstract

High affinity uptake of [14C]glutamate into rat striatal synaptosomes was reduced by 33% after bilateral cortical ablation. The lesion had no effect on striatal [14C]GABA uptake, but reduced 2-oxo-[14C]glutarate uptake by 67%. The results demonstrate the existence of a high-affinity uptake site for 2-oxoglutarate on glutamatergic nerve terminals and support the contention that this Krebs cycle intermediate may be used to replenish the neuronal pool of neurotransmitter glutamate. 2-Oxo-[14C]glutarate uptake may serve as a selective marker for glutamatergic neurones.

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Year:  1986        PMID： 2880322     DOI： 10.1016/0304-3940(86)90085-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  3 in total

1.  Uptake and metabolism of glutamate and aspartate by astroglial and neuronal preparations of rat cerebellum.

Authors:  V L Rao; C R Murthy
Journal:  Neurochem Res       Date:  1993-06       Impact factor: 3.996

2.  Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy.

Authors:  L Faff-Michalak; J Albrecht
Journal:  Metab Brain Dis       Date:  1991-12       Impact factor: 3.584

3.  Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo.

Authors:  Laura M McNair; Graeme F Mason; Golam Mi Chowdhury; Lihong Jiang; Xiaoxian Ma; Douglas L Rothman; Helle S Waagepetersen; Kevin L Behar
Journal:  J Cereb Blood Flow Metab       Date:  2022-01-20       Impact factor: 6.960
  3 in total

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