Youn Ho Sheen1, Mary C Rolfes2, Chung-Il Wi3, Cindy S Crowson4, Richard S Pendegraft5, Katherine S King5, Euijung Ryu5, Young J Juhn6. 1. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea. 2. Mayo Medical School, Rochester, Minn. 3. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn. 4. Division of Health Sciences and Research, Mayo Clinic, Rochester, Minn; Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minn. 5. Division of Health Sciences and Research, Mayo Clinic, Rochester, Minn. 6. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minn; Department of Pediatric and Adolescent Medicine/Internal Medicine, Mayo Clinic, Rochester, Minn. Electronic address: Juhn.young@mayo.edu.
Abstract
BACKGROUND: TH1 and TH2 cells have counterregulatory relationships. However, the relationship between asthma, a TH2-predominant condition, and risk of systemic inflammatory diseases such as rheumatoid arthritis (RA), a TH1 condition, is poorly understood. OBJECTIVE: We aimed to determine whether asthma was associated with increased risks of incident RA among adults. METHODS: We conducted a retrospective population-based case-control study that examined existing incident RA cases and controls matched by age, sex, and registration year from the general population in Olmsted County, Minnesota, between January 2002 and December 2007. We performed comprehensive medical record reviews to ascertain asthma status using predetermined asthma criteria. The frequency of a history of asthma before the index date was compared between cases and controls. Logistic regression models were used to adjust for confounding factors. RESULTS: We enrolled 221 RA cases and 218 controls. Of the 221 RA cases, 156 (70.6%) were females, 207 (93.7%) were white, the median age at the index date was 52.5 years, and 53 (24.0%) had a history of asthma. Controls had similar characteristics except that 35 of 218 controls (16.1%) had a history of asthma. After adjustment for sex, age, smoking, body mass index, socioeconomic status, and comorbidity, asthma was significantly associated with increased risks of RA (adjusted odds ratio, 1.74; 95% CI, 1.05-2.90; P = .03). CONCLUSIONS: Despite the counterregulatory relationship between TH1 and TH2 cells, patients with asthma had a significantly higher risk of developing RA than healthy individuals.
BACKGROUND:TH1 and TH2 cells have counterregulatory relationships. However, the relationship between asthma, a TH2-predominant condition, and risk of systemic inflammatory diseases such as rheumatoid arthritis (RA), a TH1 condition, is poorly understood. OBJECTIVE: We aimed to determine whether asthma was associated with increased risks of incident RA among adults. METHODS: We conducted a retrospective population-based case-control study that examined existing incident RA cases and controls matched by age, sex, and registration year from the general population in Olmsted County, Minnesota, between January 2002 and December 2007. We performed comprehensive medical record reviews to ascertain asthma status using predetermined asthma criteria. The frequency of a history of asthma before the index date was compared between cases and controls. Logistic regression models were used to adjust for confounding factors. RESULTS: We enrolled 221 RA cases and 218 controls. Of the 221 RA cases, 156 (70.6%) were females, 207 (93.7%) were white, the median age at the index date was 52.5 years, and 53 (24.0%) had a history of asthma. Controls had similar characteristics except that 35 of 218 controls (16.1%) had a history of asthma. After adjustment for sex, age, smoking, body mass index, socioeconomic status, and comorbidity, asthma was significantly associated with increased risks of RA (adjusted odds ratio, 1.74; 95% CI, 1.05-2.90; P = .03). CONCLUSIONS: Despite the counterregulatory relationship between TH1 and TH2 cells, patients with asthma had a significantly higher risk of developing RA than healthy individuals.
Authors: S Molet; Q Hamid; F Davoine; E Nutku; R Taha; N Pagé; R Olivenstein; J Elias; J Chakir Journal: J Allergy Clin Immunol Date: 2001-09 Impact factor: 10.793
Authors: Bharath Manu Akkara Veetil; Elena Myasoedova; Eric L Matteson; Sherine E Gabriel; Abigail B Green; Cynthia S Crowson Journal: Arthritis Care Res (Hoboken) Date: 2013-06 Impact factor: 4.794
Authors: Vanessa L Kronzer; Cynthia S Crowson; Jeffrey A Sparks; Robert Vassallo; John M Davis Journal: Arthritis Rheumatol Date: 2019-07-01 Impact factor: 10.995
Authors: H Maura Friedlander; Julia A Ford; Alessandra Zaccardelli; Alexsandra V Terrio; Michael H Cho; Jeffrey A Sparks Journal: Expert Rev Clin Immunol Date: 2020-01-06 Impact factor: 4.473
Authors: Julia A Ford; Xinyi Liu; Su H Chu; Bing Lu; Michael H Cho; Edwin K Silverman; Karen H Costenbader; Carlos A Camargo; Jeffrey A Sparks Journal: Arthritis Rheumatol Date: 2020-04-03 Impact factor: 10.995
Authors: Vanessa L Kronzer; Weixing Huang; Alessandra Zaccardelli; Cynthia S Crowson; John M Davis; Robert Vassallo; Tracy J Doyle; Elena Losina; Jeffrey A Sparks Journal: J Rheumatol Date: 2021-10-15 Impact factor: 4.666
Authors: Vanessa L Kronzer; Weixing Huang; Cynthia S Crowson; John M DavisIII; Robert Vassallo; Tracy J Doyle; Elena Losina; Jeffrey A Sparks Journal: Semin Arthritis Rheum Date: 2021-12-31 Impact factor: 5.532
Authors: Alessandra Zaccardelli; Xinyi Liu; Julia A Ford; Jing Cui; Bing Lu; Su H Chu; Peter H Schur; Cameron B Speyer; Karen H Costenbader; William H Robinson; Jeremy Sokolove; Elizabeth W Karlson; Carlos A Camargo; Jeffrey A Sparks Journal: Arthritis Res Ther Date: 2019-11-21 Impact factor: 5.156