Literature DB >> 2880318

Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord.

W Endres, K Ballanyi, G Serve, P Grafe.   

Abstract

Double-barrelled pH-sensitive micro-electrodes were used to measure changes of intracellular and extracellular pH in and around motoneurons of the isolated frog spinal cord during application of excitatory amino acids. It was found that N-methyl-D-aspartate, quisqualate and kainate produced a concentration-dependent intracellular acidification. Extracellularly, triphasic pH changes (acid-alkaline-acid going pH transients) were observed during the action of these amino acids. The possible significance of such pH changes for the physiological and pathophysiological effects of excitatory amino acids are discussed.

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Year:  1986        PMID： 2880318     DOI： 10.1016/0304-3940(86)90617-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  Acidosis of rat dorsal vagal neurons in situ during spontaneous and evoked activity.

Authors:  S Trapp; M Lückermann; P A Brooks; K Ballanyi
Journal:  J Physiol       Date:  1996-11-01       Impact factor: 5.182

2.  Intracellular pH of astrocytes increases rapidly with cortical stimulation.

Authors:  M Chesler; R P Kraig
Journal:  Am J Physiol       Date:  1987-10

3.  Changes in the surface pH of voltage-clamped snail neurones apparently caused by H+ fluxes through a channel.

Authors:  R C Thomas
Journal:  J Physiol       Date:  1988-04       Impact factor: 5.182

4.  Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.

Authors:  Tushare Jinadasa; Elöd Z Szabó; Masayuki Numat; John Orlowski
Journal:  J Biol Chem       Date:  2014-07-25       Impact factor: 5.157

5.  Intracellular pH transients of mammalian astrocytes.

Authors:  M Chesler; R P Kraig
Journal:  J Neurosci       Date:  1989-06       Impact factor: 6.167

Review 6.  31P-MRS-based determination of brain intracellular and interstitial pH: its application to in vivo H+ compartmentation and cellular regulation during hypoxic/ischemic conditions.

Authors:  D B Kintner; M K Anderson; J H Fitzpatrick; K A Sailor; D D Gilboe
Journal:  Neurochem Res       Date:  2000-10       Impact factor: 3.996

7.  Vesicular ATPase inserted into the plasma membrane of motor terminals by exocytosis alkalinizes cytosolic pH and facilitates endocytosis.

Authors:  Zhongsheng Zhang; Khanh T Nguyen; Ellen F Barrett; Gavriel David
Journal:  Neuron       Date:  2010-12-22       Impact factor: 17.173

8.  Na+ /H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals.

Authors:  Adam J Rossano; Akira Kato; Karyl I Minard; Michael F Romero; Gregory T Macleod
Journal:  J Physiol       Date:  2016-11-13       Impact factor: 5.182

9.  Extracellular alkalinization evoked by GABA and its relationship to activity-dependent pH shifts in turtle cerebellum.

Authors:  J C Chen; M Chesler
Journal:  J Physiol       Date:  1991-10       Impact factor: 5.182

10.  Genetically encoded pH-indicators reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo.

Authors:  Adam J Rossano; Amit K Chouhan; Gregory T Macleod
Journal:  J Physiol       Date:  2013-01-07       Impact factor: 5.182
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