Sonomi Nakajima1, Yasuaki Saijo2, Chihiro Miyashita3, Tamiko Ikeno4, Seiko Sasaki5, Junboku Kajiwara6, Reiko Kishi7. 1. School of Health Sciences, Sapporo Medical University, Minami 1, Nishi 17, Chuo-ku, Sapporo 060-8556, Japan. Electronic address: sonomi@sapmed.ac.jp. 2. Department of Health Sciences, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa 078-8510, Japan. Electronic address: y-saijo@asahikawa-med.ac.jp. 3. Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: miyasita@med.hokudai.ac.jp. 4. Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: tikeno@cehs.hokudai.ac.jp. 5. Department of Public Health, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan. Electronic address: sasakis@med.hokudai.ac.jp. 6. Fukuoka Institute of Health and Environmental Sciences, Mukaizano 39, Dazaifu 818-0135, Japan. Electronic address: kajiwara@fihes.pref.fukuoka.jp. 7. Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: rkishi@med.hokudai.ac.jp.
Abstract
BACKGROUND: Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known. OBJECTIVES: We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects. METHODS: The levels of all and each individual DLC isomers were estimated in maternal peripheral blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development-2nd Edition for 6-month-old infants (n = 190) and 18-month-old children (n = 121). RESULTS: In male children, levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables. However, at 18 months of age, these associations were absent. In female children, the level of only one DLC isomer was significantly negatively associated with PDI at 6 months of age. However, in contrast to the male children, the levels of six DLC isomers in 18-month-old female children were significantly positively associated with the Mental Developmental Index. CONCLUSIONS: These findings indicate that adverse neurodevelopmental effects of prenatal background-level exposure to DLCs may be stronger in male children.
BACKGROUND: Consistent reports are not available on the effects of dioxin-like polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD)/ polychlorinated dibenzofurans (PCDF) (dioxin-like compounds [DLCs]) on child neurodevelopment. Further, the effect of background-level exposure to individual DLC isomers is not known. OBJECTIVES: We carried out the Sapporo cohort study to evaluate the effect of prenatal exposure to each DLC isomer on child neurodevelopment at 6 and 18 months of age, and assessed sex-specific differences in these effects. METHODS: The levels of all and each individual DLC isomers were estimated in maternal peripheral blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development-2nd Edition for 6-month-old infants (n = 190) and 18-month-old children (n = 121). RESULTS: In male children, levels of 10 DLC isomers were significantly negatively associated with the Psychomotor Developmental Index (PDI) at 6 months of age after adjustment for potential confounding variables. However, at 18 months of age, these associations were absent. In female children, the level of only one DLC isomer was significantly negatively associated with PDI at 6 months of age. However, in contrast to the male children, the levels of six DLC isomers in 18-month-old female children were significantly positively associated with the Mental Developmental Index. CONCLUSIONS: These findings indicate that adverse neurodevelopmental effects of prenatal background-level exposure to DLCs may be stronger in male children.
Authors: Jennifer Ames; Marcella Warner; Claudia Siracusa; Stefano Signorini; Paolo Brambilla; Paolo Mocarelli; Brenda Eskenazi Journal: Int J Hyg Environ Health Date: 2019-01-09 Impact factor: 5.840
Authors: Lisa B Rokoff; Jessica R Shoaff; Brent A Coull; Michelle Bosquet Enlow; David C Bellinger; Susan A Korrick Journal: Environ Res Date: 2022-01-10 Impact factor: 6.498