Yi Wan1, Jusheng Zheng2, Fenglei Wang1, Duo Li3,4. 1. Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 2. MRC Epidemiology Unit, University of Cambridge, Cambridge, UK. 3. Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. Email: duoli@zju.edu.cn; duoli@qdu.edu.cn. 4. Institute of Nutrition and Health, Qingdao University, Qingdao, China.
Abstract
BACKGROUND AND OBJECTIVES: The consumption of fish and long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) may influence the risk of all-cause mortality, but the findings have been inconsistent. The current systematic review and meta-analysis is to clarify the association between fish and long chain n-3 PUFA consumption with risk of all-cause mortality. METHODS AND STUDY DESIGN: Studies published before March 2017 were identified through electronic searches using PubMed, Scopus and Web of Science database. We included prospective cohort studies that reported relative risks with 95% CI of all-cause mortality for fish and long chain n-3 PUFA consumption. Results were combined using a random effects model. RESULTS: Twenty-three prospective cohorts with a total of 1,035,416 participants were included. Twenty-two pooled studies involving 985,126 participants indicated that fish intake was associated with 6% (RR: 0.94; 95% CI: 0.90, 0.98) reduction in risk of all-cause mortality. Six studies with 430,579 participants investigated the association between long chain n-3 PUFA and all-cause mortality risk, the relative risk for highest versus lowest category was 0.86 (95% CI: 0.80, 0.93). Doseresponse analysis suggested that the risk of all-cause mortality was reduced by 7% (RR: 0.93; 95% CI: 0.88, 0.99) for every 0.2 g per day increment in long chain n-3 PUFA consumption. CONCLUSIONS: Current meta-analysis indicates that both fish and long chain n-3 PUFA consumption are inversely associated with risk of all-cause mortality. These findings could have public health implications with regard to lowering risk of all-cause mortality through dietary interventions.
BACKGROUND AND OBJECTIVES: The consumption of fish and long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) may influence the risk of all-cause mortality, but the findings have been inconsistent. The current systematic review and meta-analysis is to clarify the association between fish and long chain n-3 PUFA consumption with risk of all-cause mortality. METHODS AND STUDY DESIGN: Studies published before March 2017 were identified through electronic searches using PubMed, Scopus and Web of Science database. We included prospective cohort studies that reported relative risks with 95% CI of all-cause mortality for fish and long chain n-3 PUFA consumption. Results were combined using a random effects model. RESULTS: Twenty-three prospective cohorts with a total of 1,035,416 participants were included. Twenty-two pooled studies involving 985,126 participants indicated that fish intake was associated with 6% (RR: 0.94; 95% CI: 0.90, 0.98) reduction in risk of all-cause mortality. Six studies with 430,579 participants investigated the association between long chain n-3 PUFA and all-cause mortality risk, the relative risk for highest versus lowest category was 0.86 (95% CI: 0.80, 0.93). Doseresponse analysis suggested that the risk of all-cause mortality was reduced by 7% (RR: 0.93; 95% CI: 0.88, 0.99) for every 0.2 g per day increment in long chain n-3 PUFA consumption. CONCLUSIONS: Current meta-analysis indicates that both fish and long chain n-3 PUFA consumption are inversely associated with risk of all-cause mortality. These findings could have public health implications with regard to lowering risk of all-cause mortality through dietary interventions.
Authors: William S Harris; Nathan L Tintle; Fumiaki Imamura; Frank Qian; Andres V Ardisson Korat; Matti Marklund; Luc Djoussé; Julie K Bassett; Pierre-Hugues Carmichael; Yun-Yu Chen; Yoichiro Hirakawa; Leanne K Küpers; Federica Laguzzi; Maria Lankinen; Rachel A Murphy; Cécilia Samieri; Mackenzie K Senn; Peilin Shi; Jyrki K Virtanen; Ingeborg A Brouwer; Kuo-Liong Chien; Gudny Eiriksdottir; Nita G Forouhi; Johanna M Geleijnse; Graham G Giles; Vilmundur Gudnason; Catherine Helmer; Allison Hodge; Rebecca Jackson; Kay-Tee Khaw; Markku Laakso; Heidi Lai; Danielle Laurin; Karin Leander; Joan Lindsay; Renata Micha; Jaako Mursu; Toshiharu Ninomiya; Wendy Post; Bruce M Psaty; Ulf Risérus; Jennifer G Robinson; Aladdin H Shadyab; Linda Snetselaar; Aleix Sala-Vila; Yangbo Sun; Lyn M Steffen; Michael Y Tsai; Nicholas J Wareham; Alexis C Wood; Jason H Y Wu; Frank Hu; Qi Sun; David S Siscovick; Rozenn N Lemaitre; Dariush Mozaffarian Journal: Nat Commun Date: 2021-04-22 Impact factor: 14.919