| Literature DB >> 2880216 |
F Diaz-Mitoma, W J Vanast, D L Tyrrell.
Abstract
In a case-control study 27 (84%) of 32 patients with new daily persistent headaches (NDPH) and 8 (25%) of 32 controls had evidence of Epstein-Barr virus (EBV) "active" infection, as demonstrated by EBV excretion and/or early antigen titre above 1:32. 20 (62%) patients and 4 (12%) controls were excreting EBV in the oropharynx, as determined by a dot hybridisation assay. The mean titre of IgG antibodies to early antigen was significantly higher in patients than controls. EBV reactivation may be important in the pathogenesis of NDPH. Alternatively, patients with NDPH may be unusually prone to EBV reactivation.Entities:
Mesh：
Substances：
Year: 1987 PMID： 2880216 DOI： 10.1016/s0140-6736(87)90119-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321