Literature DB >> 28800914

Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown!

Emma V Watson1, Stephen J Elledge2.   

Abstract

Aneuploidy is ubiquitous in cancer and plays a pivotal, early role in tumor evolution. It must therefore be avoided, and two recent papers highlight the roles of p53, senescence, and the immune system in preventing the outgrowth of aneuploid clones in tissue culture. These mechanisms are likely to synergize to maintain diploid cell populations.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  NK cells; aneuploidy; p53; senescence; single-cell sequencing

Mesh：

Year:  2017        PMID： 28800914     DOI： 10.1016/j.tig.2017.07.007

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  6 in total

1.  Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Authors:  Boying Guo; Alicia Rodriguez-Gabin; Andrea E Prota; Tobias Mühlethaler; Nan Zhang; Kenny Ye; Michel O Steinmetz; Susan Band Horwitz; Amos B Smith; Hayley M McDaid
Journal:  Mol Pharmacol       Date:  2020-06-26       Impact factor: 4.436

2.  Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes.

Authors:  Ruoxi W Wang; Emily MacDuffie; Stefano Santaguida
Journal:  J Vis Exp       Date:  2018-04-13       Impact factor: 1.355

Review 3.  DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons.

Authors:  Therese Wilhelm; Maha Said; Valeria Naim
Journal:  Genes (Basel)       Date:  2020-06-10       Impact factor: 4.096

4.  On the role of p53 in the cellular response to aneuploidy.

Authors:  Akshay Narkar; Blake A Johnson; Pandurang Bharne; Jin Zhu; Veena Padmanaban; Debojyoti Biswas; Andrew Fraser; Pablo A Iglesias; Andrew J Ewald; Rong Li
Journal:  Cell Rep       Date:  2021-03-23       Impact factor: 9.423

5.  Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Caenorhabditis elegans Model.

Authors:  Hyemin Min; Mijin Lee; Kyoung Sang Cho; Hyunjung Jade Lim; Yhong-Hee Shim
Journal:  Antioxidants (Basel)       Date:  2021-03-26

Review 6.  Karyotype Aberrations in Action: The Evolution of Cancer Genomes and the Tumor Microenvironment.

Authors:  Nicolaas C Baudoin; Mathew Bloomfield
Journal:  Genes (Basel)       Date:  2021-04-12       Impact factor: 4.096
  6 in total

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