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Literature DB >> 2879972

Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.

R Yarchoan, G Berg, P Brouwers, M A Fischl, A R Spitzer, A Wichman, J Grafman, R V Thomas, B Safai, A Brunetti.

Abstract

Four patients with human-immuno-deficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.

Entities: Chemical Disease Species

Mesh：

Substances：
Zidovudine
Thymidine

Year: 1987 PMID： 2879972 DOI： 10.1016/s0140-6736(87)91968-4

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

58 in total

Review 1. Antiretroviral therapy: reverse transcriptase inhibition.

Authors: K J Connolly; S M Hammer
Journal: Antimicrob Agents Chemother Date: 1992-02 Impact factor: 5.191

2. Failure to maintain high-dose treatment regimens during long-term use of zidovudine in patients with symptomatic human immunodeficiency virus type 1 infection.

Authors: R van Leeuwen; P J van den Hurk; G J Jöbsis; P A van der Wouw; P Reiss; J K Eeftinck Schattenkerk; S A Danner; J M Lange
Journal: Genitourin Med Date: 1990-12

3. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia.

Authors: I P Everall; J D Glass; J McArthur; E Spargo; P Lantos
Journal: Acta Neuropathol Date: 1994 Impact factor: 17.088

Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.

Review 1. Antiretroviral therapy: reverse transcriptase inhibition.

2. Failure to maintain high-dose treatment regimens during long-term use of zidovudine in patients with symptomatic human immunodeficiency virus type 1 infection.

3. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia.

4. Declining incidence of AIDS dementia complex after introduction of zidovudine treatment.

5. Early HIV detection: a community mental health role.

Review 6. Clinical pharmacology of zidovudine and other 2',3'-dideoxynucleoside analogues.

Review 7. The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic.

Review 8. Review of antiretroviral therapy in the prevention of HIV-related AIDS dementia complex (ADC).

Review 9. Neurologic and psychiatric manifestations of HIV disease.

Review 10. Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.