Hidetatsu Outani1,2, Yoshinori Imura3, Takaaki Tanaka3, Satoshi Takenaka4, Kazuya Oshima3, Kenichiro Hamada4, Shigeki Kakunaga5, Susumu Joyama6, Norifumi Naka3, Ikuo Kudawara5, Takafumi Ueda5, Nobuhito Araki3, Hideki Yoshikawa4. 1. Musculoskeletal Oncology Service, Osaka International Cancer Institute, 3-1-69 Otemae, Chuou-ku, Osaka, 541-8567, Japan. h-otani@ort.med.osaka-u.ac.jp. 2. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. h-otani@ort.med.osaka-u.ac.jp. 3. Musculoskeletal Oncology Service, Osaka International Cancer Institute, 3-1-69 Otemae, Chuou-ku, Osaka, 541-8567, Japan. 4. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. 5. Department of Orthopaedic Surgery, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan. 6. Department of Orthopaedic Surgery, Kawachi General Hospital, 1-31 Yokomakura, Higashiosaka, Osaka, 578-0954, Japan.
Abstract
PURPOSE: An epithelioid sarcoma is a rare histological subtype of a soft tissue sarcoma with a high local recurrence rate, which frequently shows lymph node metastasis. However, because of the rarity of this tumor, the impact of nodal metastasis and its appropriate management remain unclear. The present study investigated the clinical outcomes of patients with epithelioid sarcomas, with a focus on lymph node metastasis. METHODS: We retrospectively evaluated the clinical outcomes of 27 patients with epithelioid sarcomas treated between 1985 and 2015. The log-rank test was used to assess the prognostic variables. RESULTS: The overall local recurrence rate was 33%, and the estimated overall 5-year survival rate was 62%. Hand and foot locations were associated with favorable overall survival. During the follow-up period, new nodal metastasis was noted in 14 patients (52%). The incidence of local recurrence was higher in patients with new nodal metastasis than in patients who did not develop nodal metastasis. The development of new nodal metastasis had a tendency to worsen survival; however, this association was not statistically significant. Lymphadenectomy did not affect overall survival. CONCLUSIONS: Peripheral tumor location is associated with a better prognosis. The development of new nodal metastasis tends to be associated with poor prognosis; however, among patients with nodal metastasis, resection of the metastatic lesions has a low impact on survival.
PURPOSE: An epithelioid sarcoma is a rare histological subtype of a soft tissue sarcoma with a high local recurrence rate, which frequently shows lymph node metastasis. However, because of the rarity of this tumor, the impact of nodal metastasis and its appropriate management remain unclear. The present study investigated the clinical outcomes of patients with epithelioid sarcomas, with a focus on lymph node metastasis. METHODS: We retrospectively evaluated the clinical outcomes of 27 patients with epithelioid sarcomas treated between 1985 and 2015. The log-rank test was used to assess the prognostic variables. RESULTS: The overall local recurrence rate was 33%, and the estimated overall 5-year survival rate was 62%. Hand and foot locations were associated with favorable overall survival. During the follow-up period, new nodal metastasis was noted in 14 patients (52%). The incidence of local recurrence was higher in patients with new nodal metastasis than in patients who did not develop nodal metastasis. The development of new nodal metastasis had a tendency to worsen survival; however, this association was not statistically significant. Lymphadenectomy did not affect overall survival. CONCLUSIONS: Peripheral tumor location is associated with a better prognosis. The development of new nodal metastasis tends to be associated with poor prognosis; however, among patients with nodal metastasis, resection of the metastatic lesions has a low impact on survival.
Authors: Sebastiaan A H J de Visscher; Robbert J van Ginkel; Theo Wobbes; René P H Veth; Suzanne E Ten Heuvel; Albert J H Suurmeijer; Harad J Hoekstra Journal: Cancer Date: 2006-08-01 Impact factor: 6.860
Authors: Antonin Levy; Cécile Le Péchoux; Philippe Terrier; Ryan Bouaita; Julien Domont; Olivier Mir; Sarah Coppola; Charles Honoré; Axel Le Cesne; Sylvie Bonvalot Journal: Ann Surg Oncol Date: 2013-09-18 Impact factor: 5.344
Authors: A Daigeler; C Kuhnen; R Moritz; I Stricker; O Goertz; D Tilkorn; L Steinstraesser; H U Steinau; M Lehnhardt Journal: Langenbecks Arch Surg Date: 2008-07-02 Impact factor: 3.445