Byung-Su Kim1, Pil-Wook Chung1, Kwang-Yeol Park1, Hong-Hee Won1, Oh Young Bang1, Chin-Sang Chung1, Kwang Ho Lee1, Gyeong-Moon Kim2. 1. From the Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea (B.-S.K.); Department of Neurology, Samsung Medical Center (B.-S.K., O.Y.B., C.-S.C., K.H.L., G.-M.K) and Department of Neurology, Kangbuk Samsung Hospital (P.-W.C.), Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea (K.-Y.P.); and Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea (H.-H.W.). 2. From the Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea (B.-S.K.); Department of Neurology, Samsung Medical Center (B.-S.K., O.Y.B., C.-S.C., K.H.L., G.-M.K) and Department of Neurology, Kangbuk Samsung Hospital (P.-W.C.), Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea (K.-Y.P.); and Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea (H.-H.W.). kimgm@skku.edu.
Abstract
BACKGROUND AND PURPOSE: Ischemic stroke patients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS: This was a retrospective cohort study analyzing data from a prospective stroke registry enrolling consecutive patients with acute ischemic stroke or transient ischemic attack. A total of 1081 patients were categorized into no ICAS, single ICAS, and advanced ICAS (ICAS ≥2 different intracranial arteries) groups. Primary and secondary end points were time to occurrence of recurrent ischemic stroke and composite vascular outcome, respectively. Study end points by ICAS burden were compared using Cox proportional hazards models in overall and propensity-matched patients. RESULTS: ICAS was present in 405 patients (37.3%). During a median 5-year follow-up, recurrent stroke and composite vascular outcome occurred in 6.8% and 16.8% of patients, respectively. As the number of ICAS increased, the risk for study end points increased after adjustment of potential covariates (hazard ratio per 1 increase in ICAS, 1.19; 95% confidence interval, 1.01-1.42 for recurrent ischemic stroke and hazard ratio, 1.18; 95% confidence interval, 1.05-1.33 for composite vascular outcome). The hazard ratios (95% confidence interval) for recurrent stroke and composite vascular outcome in patients with advanced ICAS compared with those without ICAS were 1.56 (0.88-2.74) and 1.72 (1.17-2.53), respectively, in the overall patients. The corresponding values in the propensity-matched patients were 1.28 (0.71-2.30) and 1.95 (1.27-2.99), respectively. CONCLUSIONS: ICAS burden was independently associated with the risk of subsequent composite vascular outcome in patients with ischemic stroke. These findings suggest that ICAS burden can reflect the risk of long-term vascular outcome.
BACKGROUND AND PURPOSE:Ischemic strokepatients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS: This was a retrospective cohort study analyzing data from a prospective stroke registry enrolling consecutive patients with acute ischemic stroke or transient ischemic attack. A total of 1081 patients were categorized into no ICAS, single ICAS, and advanced ICAS (ICAS ≥2 different intracranial arteries) groups. Primary and secondary end points were time to occurrence of recurrent ischemic stroke and composite vascular outcome, respectively. Study end points by ICAS burden were compared using Cox proportional hazards models in overall and propensity-matched patients. RESULTS: ICAS was present in 405 patients (37.3%). During a median 5-year follow-up, recurrent stroke and composite vascular outcome occurred in 6.8% and 16.8% of patients, respectively. As the number of ICAS increased, the risk for study end points increased after adjustment of potential covariates (hazard ratio per 1 increase in ICAS, 1.19; 95% confidence interval, 1.01-1.42 for recurrent ischemic stroke and hazard ratio, 1.18; 95% confidence interval, 1.05-1.33 for composite vascular outcome). The hazard ratios (95% confidence interval) for recurrent stroke and composite vascular outcome in patients with advanced ICAS compared with those without ICAS were 1.56 (0.88-2.74) and 1.72 (1.17-2.53), respectively, in the overall patients. The corresponding values in the propensity-matched patients were 1.28 (0.71-2.30) and 1.95 (1.27-2.99), respectively. CONCLUSIONS: ICAS burden was independently associated with the risk of subsequent composite vascular outcome in patients with ischemic stroke. These findings suggest that ICAS burden can reflect the risk of long-term vascular outcome.
Authors: Jose G Romano; Shyam Prabhakaran; Azhar Nizam; Edward Feldmann; Rajbeer Sangha; George Cotsonis; Iszet Campo-Bustillo; Sebastian Koch; Tatjana Rundek; Marc I Chimowitz; David S Liebeskind Journal: J Stroke Cerebrovasc Dis Date: 2020-12-01 Impact factor: 2.136
Authors: Xinyi Leng; Robert Hurford; Xueyan Feng; Ka Lung Chan; Frank J Wolters; Linxin Li; Yannie Oy Soo; Ka Sing Lawrence Wong; Vincent Ct Mok; Thomas W Leung; Peter M Rothwell Journal: J Neurol Neurosurg Psychiatry Date: 2021-03-30 Impact factor: 10.154
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