Sadiye Altun Tuzcu1, Zafer Pekkolay2, Faruk Kılınç2, Alpaslan Kemal Tuzcu2. 1. Department of Nuclear Medicine, Gazi Yasargil Education and Research Hospital, Diyarbakır, Turkey; and sadiyetuzcu@yahoo.com.tr. 2. Department of Endocrinology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Abstract
Insulinomas are the most common cause of hypoglycemia, resulting from endogenous hyperinsulinism. The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin concentrations during a spontaneous or induced episode of hypoglycemia. Most insulinomas are islet-cell tumors. They are often small (<2 cm), benign, and difficult to localize with current imaging techniques. Insulinomas can be detected using either noninvasive procedures (e.g., transabdominal ultrasonography, spiral CT, MRI, 111In-pentetreotide imaging, and 18F-l-dihydroxyphenylalanine PET) or invasive procedures (e.g., endoscopic ultrasonography) or a selective arterial calcium stimulation test with hepatic venous sampling. Methods: We performed 68Ga-DOTATATE PET/CT on 3 patients with insulinoma. Results: All patients' insulinomas were shown clearly with 68Ga-DOTATATE PET/CT. Conclusion: 68Ga-DOTATATE PET/CT imaging may be a useful noninvasive imaging technique to localize insulinomas preoperatively.
Insulinomas are the most common cause of hypoglycemia, resulting from endogenous hyperinsulinism. The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin concentrations during a spontaneous or induced episode of hypoglycemia. Most insulinomas are islet-cell tumors. They are often small (<2 cm), benign, and difficult to localize with current imaging techniques. Insulinomas can be detected using either noninvasive procedures (e.g., transabdominal ultrasonography, spiral CT, MRI, 111In-pentetreotide imaging, and 18F-l-dihydroxyphenylalanine PET) or invasive procedures (e.g., endoscopic ultrasonography) or a selective arterial calcium stimulation test with hepatic venous sampling. Methods: We performed 68Ga-DOTATATE PET/CT on 3 patients with insulinoma. Results: All patients' insulinomas were shown clearly with 68Ga-DOTATATE PET/CT. Conclusion: 68Ga-DOTATATE PET/CT imaging may be a useful noninvasive imaging technique to localize insulinomas preoperatively.
Authors: Maria Gϋemes; Sofia Asim Rahman; Ritika R Kapoor; Sarah Flanagan; Jayne A L Houghton; Shivani Misra; Nick Oliver; Mehul Tulsidas Dattani; Pratik Shah Journal: Rev Endocr Metab Disord Date: 2020-12 Impact factor: 6.514