Literature DB >> 28797798

Achyrodimer F, a tyrosyl-DNA phosphodiesterase I inhibitor from an Australian fungus of the family Cortinariaceae.

Li-Wen Tian1, Yunjiang Feng1, Trong D Tran1, Yoko Shimizu2, Tom Pfeifer2, Hoan T Vu1, Ronald J Quinn3.   

Abstract

Mass-guided isolation of the dichloromethane/methanol extracts from a specimen of teleomorphic fungus of the family Cortinariaceae resulted in the identification of a new dimeric cyclobutane metabolite, achyrodimer F (1), along with the monomers hispidin (2) and bisnoryangonin (3). Their structures were determined by NMR and MS data analyses. Density Function Theory (DFT) NMR calculations was employed to confirm the chemical structure of achyrodimer F. Compound 1 inhibited tyrosyl-DNA phosphodiesterase I with an IC50 value of 1μM.
Copyright © 2017. Published by Elsevier Ltd.

Entities:  

Keywords:  Achyrodimer F; Cyclobutane derivative; DFT calculations; Fungus Cortinariaceae; Tdp1

Mesh：

Substances：

Year:  2017        PMID： 28797798     DOI： 10.1016/j.bmcl.2017.07.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Is it time for artificial intelligence to predict the function of natural products based on 2D-structure.

Authors:  Miaomiao Liu; Peter Karuso; Yunjiang Feng; Esther Kellenberger; Fei Liu; Can Wang; Ronald J Quinn
Journal:  Medchemcomm       Date:  2019-06-06       Impact factor: 3.597

Review 2.  Therapeutic Potential of Hispidin-Fungal and Plant Polyketide.

Authors:  Kseniia A Palkina; Daria A Ipatova; Ekaterina S Shakhova; Anastasia V Balakireva; Nadezhda M Markina
Journal:  J Fungi (Basel)       Date:  2021-04-22

3.  A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Authors:  Nikolai S Li-Zhulanov; Alexandra L Zakharenko; Arina A Chepanova; Jinal Patel; Ayesha Zafar; Konstantin P Volcho; Nariman F Salakhutdinov; Jóhannes Reynisson; Ivanhoe K H Leung; Olga I Lavrik
Journal:  Molecules       Date:  2018-09-26       Impact factor: 4.411

4.  Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts.

Authors:  Evan J Brettrager; Robert C A M van Waardenburg
Journal:  Cancer Drug Resist       Date:  2019-12-19

5.  Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.

Authors:  Tatyana M Khomenko; Alexandra L Zakharenko; Arina A Chepanova; Ekaterina S Ilina; Olga D Zakharova; Vasily I Kaledin; Valeriy P Nikolin; Nelly A Popova; Dina V Korchagina; Jóhannes Reynisson; Raina Chand; Daniel M Ayine-Tora; Jinal Patel; Ivanhoe K H Leung; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Int J Mol Sci       Date:  2019-12-23       Impact factor: 5.923

Review 6.  Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.

Authors:  Ajinkya S Kawale; Lawrence F Povirk
Journal:  Nucleic Acids Res       Date:  2018-01-25       Impact factor: 16.971

7.  A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.

Authors:  Ann-Katrine Jakobsen; Josephine Geertsen Keller; María Gonzalez; Endika Martin-Encinas; Francisco Palacios; Concepcion Alonso; Birgitta Ruth Knudsen; Magnus Stougaard
Journal:  Sensors (Basel)       Date:  2021-07-15       Impact factor: 3.576
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.