Literature DB >> 2879707

Detection of two TaqI polymorphisms in the VTR region of the human HRAS1 oncogene.

M A Pierotti, P Radice, I Biunno, M G Borrello, M R Cattadori, G Della Porta.   

Abstract

Restriction enzyme analysis of the variable tandem repetition (VTR) region of the human HRAS1 oncogene revealed two TaqI polymorphisms. The first polymorphism overlaps that detected with MspI/HpaII restriction enzymes and is due to a variable number of repeat units which form the VTR region at the 3' end of the oncogene. The second polymorphism appears to be due to two new TaqI restriction sites created within the VTR region itself. This novel polymorphism was detected in 26 of 145 human DNA samples and was found to segregate in a Mendelian fashion.

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Year:  1986        PMID： 2879707     DOI： 10.1159/000132317

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  6 in total

1.  Evidence of a long QT founder gene with varying phenotypic expression in South African families.

Authors:  T de Jager; C H Corbett; J C Badenhorst; P A Brink; V A Corfield
Journal:  J Med Genet       Date:  1996-07       Impact factor: 6.318

2.  TaqI polymorphism within the c-Ha-ras-1 VTR is associated with melanoma.

Authors:  N K Hayward; D J Nancarrow; P G Parsons; C Kidson; K A Ellem
Journal:  Hum Genet       Date:  1989-11       Impact factor: 4.132

3.  Loss of allelic heterozygosity at the harvey ras locus in human oral carcinomas.

Authors:  D Saranath; L T Bhoite; A R Mehta; V Sanghavi; M G Deo
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

4.  Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours.

Authors:  M Mannens; R M Slater; C Heyting; J Bliek; J de Kraker; N Coad; P de Pagter-Holthuizen; P L Pearson
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

5.  Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.

Authors:  L Ceccherini-Nelli; V De Re; A Viel; G Molaro; L Zilli; C Clemente; M Boiocchi
Journal:  Br J Cancer       Date:  1987-07       Impact factor: 7.640

6.  Structure and expression of oncogenes in surgical specimens of human breast carcinomas.

Authors:  I Biunno; M R Pozzi; M A Pierotti; S Pilotti; G Cattoretti; G Della Porta
Journal:  Br J Cancer       Date:  1988-05       Impact factor: 7.640
  6 in total

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