Song Wu1,2, Wei Zhu1,2, Yusuf A Hannun2,3,4,5. 1. Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794, USA. 2. Stony Brook Cancer Center, Stony Brook University, Health Sciences Center, Stony Brook, New York 11794, USA. 3. Department of Pathology, Stony Brook University, Health Sciences Center, Stony Brook, New York 11794, USA. 4. Department of Medicine, Stony Brook University, Health Sciences Center, Stony Brook, New York 11794, USA. 5. Department of Biochemistry, Stony Brook University, Health Sciences Center, Stony Brook, New York 11794, USA.