Literature DB >> 2879605

Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons.

H Kamo, S U Kim, P L McGeer, D H Shin.   

Abstract

Rats subjected to a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal dopamine pathway were given transplants of cultured fetal human sympathetic neurons. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. The presence of transplanted neurons and their processes was demonstrated by immunohistochemistry for tyrosine hydroxylase.

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Year:  1986        PMID： 2879605     DOI： 10.1016/0006-8993(86)90641-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Autotransplantation of superior cervical ganglion to the caudate nucleus in three patients with Parkinson's disease (preliminary report).

Authors:  M Horvath; E Pasztor; M Palkovits; A Solyom; M Tarczy; N Lekka; E Csanda
Journal:  Neurosurg Rev       Date:  1990       Impact factor: 3.042

Review 2.  Tracking extranigral degeneration in animal models of Parkinson's disease: quest for effective therapeutic strategies.

Authors:  Varduhi H Knaryan; Supriti Samantaray; Charlene Le Gal; Swapan K Ray; Naren L Banik
Journal:  J Neurochem       Date:  2011-06-17       Impact factor: 5.372

3.  Effects of donor age on superior cervical ganglion transplants: evaluation of Falck-Hillarp histochemistry and immunocytochemistry.

Authors:  P Stieg; I Strömberg; L Olson
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

4.  Survival and function of aggregate cultures of rat fetal dopamine neurons grafted in a rat model of Parkinson's disease.

Authors:  R E Strecker; R Miao; J F Loring
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

5.  Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat.

Authors:  R Barker; S B Dunnett
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

6.  Survival and immunogenicity of dissociated allogeneic fetal neural dopamine-rich grafts when implanted into the brains of adult mice.

Authors:  H Widner; P Brundin; A Björklund; E Möller
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

7.  Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier.

Authors:  P Brundin; H Widner; O G Nilsson; R E Strecker; A Björklund
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

8.  Transplantation of cultured sympathetic ganglionic neurons into parkinsonian rat brain: survival and function of graft.

Authors:  N Nakao; T Itakura; Y Uematsu; N Komai
Journal:  Acta Neurochir (Wien)       Date:  1995       Impact factor: 2.216

9.  Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release.

Authors:  P Brundin; R E Strecker; H Widner; D J Clarke; O G Nilsson; B Astedt; O Lindvall; A Björklund
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

Review 10.  Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis.

Authors:  H Widner; P Brundin
Journal:  Brain Res       Date:  1988-11       Impact factor: 3.252
  10 in total

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