Literature DB >> 28795956

Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls.

Janet Rubin1, Maya Styner1, Gunes Uzer1.   

Abstract

Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.

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Year:  2018        PMID： 28795956      PMCID： PMC5735017          DOI： 10.1249/JES.0000000000000129

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.230


  50 in total

1.  Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: a pilot study.

Authors:  K Casazza; L J Hanks; B Hidalgo; H H Hu; O Affuso
Journal:  Bone       Date:  2011-09-13       Impact factor: 4.398

2.  Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.

Authors:  Natasha Case; Jacob Thomas; Buer Sen; Maya Styner; Zhihui Xie; Kornelia Galior; Janet Rubin
Journal:  J Biol Chem       Date:  2011-09-28       Impact factor: 5.157

3.  Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast.

Authors:  Maya Spichal; Alice Brion; Sébastien Herbert; Axel Cournac; Martial Marbouty; Christophe Zimmer; Romain Koszul; Emmanuelle Fabre
Journal:  J Cell Sci       Date:  2016-01-13       Impact factor: 5.285

4.  Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.

Authors:  Joe Swift; Irena L Ivanovska; Amnon Buxboim; Takamasa Harada; P C Dave P Dingal; Joel Pinter; J David Pajerowski; Kyle R Spinler; Jae-Won Shin; Manorama Tewari; Florian Rehfeldt; David W Speicher; Dennis E Discher
Journal:  Science       Date:  2013-08-30       Impact factor: 47.728

5.  Movement-Based Behaviors and Leukocyte Telomere Length among US Adults.

Authors:  Paul D Loprinzi; Jeremy P Loenneke; Elizabeth H Blackburn
Journal:  Med Sci Sports Exerc       Date:  2015-11       Impact factor: 5.411

6.  Bone marrow fat is inversely related to cortical bone in young and old subjects.

Authors:  Tishya A L Wren; Sandra A Chung; Frederick J Dorey; Stefan Bluml; Gregor B Adams; Vicente Gilsanz
Journal:  J Clin Endocrinol Metab       Date:  2010-12-22       Impact factor: 5.958

Review 7.  Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.

Authors:  Rick B Vega; John P Konhilas; Daniel P Kelly; Leslie A Leinwand
Journal:  Cell Metab       Date:  2017-05-02       Impact factor: 27.287

8.  Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome.

Authors:  Robert D Goldman; Dale K Shumaker; Michael R Erdos; Maria Eriksson; Anne E Goldman; Leslie B Gordon; Yosef Gruenbaum; Satya Khuon; Melissa Mendez; Renée Varga; Francis S Collins
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-07       Impact factor: 11.205

9.  Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise.

Authors:  Maya Styner; William R Thompson; Kornelia Galior; Gunes Uzer; Xin Wu; Sanjay Kadari; Natasha Case; Zhihui Xie; Buer Sen; Andrew Romaine; Gabriel M Pagnotti; Clinton T Rubin; Martin A Styner; Mark C Horowitz; Janet Rubin
Journal:  Bone       Date:  2014-04-05       Impact factor: 4.398

10.  Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.

Authors:  Olaia Naveiras; Valentina Nardi; Pamela L Wenzel; Peter V Hauschka; Frederic Fahey; George Q Daley
Journal:  Nature       Date:  2009-06-10       Impact factor: 49.962
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  8 in total

Review 1.  Epigenetics of Skeletal Diseases.

Authors:  Alvaro Del Real; Leyre Riancho-Zarrabeitia; Laura López-Delgado; José A Riancho
Journal:  Curr Osteoporos Rep       Date:  2018-06       Impact factor: 5.096

Review 2.  Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.

Authors:  Sarah E Little-Letsinger; Janet Rubin; Brian Diekman; Clinton T Rubin; Cody McGrath; Gabriel M Pagnotti; Eric L Klett; Maya Styner
Journal:  Semin Cell Dev Biol       Date:  2021-09-04       Impact factor: 7.727

3.  Isolated nuclei stiffen in response to low intensity vibration.

Authors:  Joshua Newberg; Jesse Schimpf; Kali Woods; Stacie Loisate; Paul H Davis; Gunes Uzer
Journal:  J Biomech       Date:  2020-08-28       Impact factor: 2.712

4.  Modeling stem cell nucleus mechanics using confocal microscopy.

Authors:  Zeke Kennedy; Joshua Newberg; Matthew Goelzer; Stefan Judex; Clare K Fitzpatrick; Gunes Uzer
Journal:  Biomech Model Mechanobiol       Date:  2021-08-23

5.  Stem cells and regenerative medicine in sport science.

Authors:  Claire E Stewart
Journal:  Emerg Top Life Sci       Date:  2021-10-29

6.  Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity.

Authors:  Cody McGrath; Sarah E Little-Letsinger; Jeyantt Srinivas Sankaran; Buer Sen; Zhihui Xie; Martin A Styner; Xiaopeng Zong; Weiqin Chen; Janet Rubin; Eric L Klett; Rosalind A Coleman; Maya Styner
Journal:  Front Endocrinol (Lausanne)       Date:  2022-01-25       Impact factor: 5.555

Review 7.  Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone.

Authors:  Natividad Alcorta-Sevillano; Iratxe Macías; Clara I Rodríguez; Arantza Infante
Journal:  Cells       Date:  2020-05-26       Impact factor: 6.600

8.  Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT).

Authors:  Cody McGrath; Jeyantt S Sankaran; Negin Misaghian-Xanthos; Buer Sen; Zhihui Xie; Martin A Styner; Xiaopeng Zong; Janet Rubin; Maya Styner
Journal:  J Bone Miner Res       Date:  2019-10-25       Impact factor: 6.741
  8 in total

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