Literature DB >> 28795863

A new era of studying p53-mediated transcription activation.

Wei-Li Liu1, Robert A Coleman1, Sameer K Singh1.   

Abstract

To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

Entities:  

Keywords:  3D structure; RNA polymerase II; cryo-electron microscopy; p53; transcription activation

Mesh：

Substances：

Year:  2017        PMID： 28795863      PMCID： PMC5834226          DOI： 10.1080/21541264.2017.1345354

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  38 in total

1.  Architecture of the RNA polymerase II-Mediator core initiation complex.

Authors:  C Plaschka; L Larivière; L Wenzeck; M Seizl; M Hemann; D Tegunov; E V Petrotchenko; C H Borchers; W Baumeister; F Herzog; E Villa; P Cramer
Journal:  Nature       Date:  2015-02-04       Impact factor: 49.962

2.  Biochemical Analysis of Yeast Suppressor of Ty 4/5 (Spt4/5) Reveals the Importance of Nucleic Acid Interactions in the Prevention of RNA Polymerase II Arrest.

Authors:  J Brooks Crickard; Jianhua Fu; Joseph C Reese
Journal:  J Biol Chem       Date:  2016-03-04       Impact factor: 5.157

3.  RNA polymerase I structure and transcription regulation.

Authors:  Christoph Engel; Sarah Sainsbury; Alan C Cheung; Dirk Kostrewa; Patrick Cramer
Journal:  Nature       Date:  2013-10-23       Impact factor: 49.962

4.  RNA Polymerase II cluster dynamics predict mRNA output in living cells.

Authors:  Won-Ki Cho; Namrata Jayanth; Brian P English; Takuma Inoue; J Owen Andrews; William Conway; Jonathan B Grimm; Jan-Hendrik Spille; Luke D Lavis; Timothée Lionnet; Ibrahim I Cisse
Journal:  Elife       Date:  2016-05-03       Impact factor: 8.140

5.  Unravelling mechanisms of p53-mediated tumour suppression.

Authors:  Kathryn T Bieging; Stephano Spano Mello; Laura D Attardi
Journal:  Nat Rev Cancer       Date:  2014-04-17       Impact factor: 60.716

Review 6.  Looping back to leap forward: transcription enters a new era.

Authors:  Michael Levine; Claudia Cattoglio; Robert Tjian
Journal:  Cell       Date:  2014-03-27       Impact factor: 41.582

7.  p53 oligomerization and DNA looping are linked with transcriptional activation.

Authors:  J E Stenger; P Tegtmeyer; G A Mayr; M Reed; Y Wang; P Wang; P V Hough; I A Mastrangelo
Journal:  EMBO J       Date:  1994-12-15       Impact factor: 11.598

8.  Oligomerization of the E. coli core RNA polymerase: formation of (α2ββ'ω)2-DNA complexes and regulation of the oligomerization by auxiliary subunits.

Authors:  Seema G Kansara; Maxim V Sukhodolets
Journal:  PLoS One       Date:  2011-04-20       Impact factor: 3.240

9.  Structural visualization of the p53/RNA polymerase II assembly.

Authors:  Sameer K Singh; Zhen Qiao; Lihua Song; Vijay Jani; William Rice; Edward Eng; Robert A Coleman; Wei-Li Liu
Journal:  Genes Dev       Date:  2016-12-05       Impact factor: 11.361

10.  Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

Authors:  Robert K Louder; Yuan He; José Ramón López-Blanco; Jie Fang; Pablo Chacón; Eva Nogales
Journal:  Nature       Date:  2016-03-23       Impact factor: 49.962
View more
  1 in total

1.  Structure of the p53/RNA polymerase II assembly.

Authors:  Shu-Hao Liou; Sameer K Singh; Robert H Singer; Robert A Coleman; Wei-Li Liu
Journal:  Commun Biol       Date:  2021-03-25
  1 in total

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