Literature DB >> 2879568

The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation.

J M Gutteridge.   

Abstract

Haemoglobin stimulates the peroxidation of lipids in two discernable phases. The first phase is inhibited by binding haemoglobin to the protein haptoglobin. The second phase is stimulated by complexable iron released from the haemoglobin molecule during the process of lipid peroxidation. This latter peroxidation is inhibitable by transferrin and the iron chelator desferrioxamine. Heat-denatured haemoglobin and haemin both stimulated lipid peroxidation but this is not inhibitable by haptoglobin. It is suggested that the haptoglobins play an important antioxidant role in vivo by preventing iron-stimulated formation of oxygen radicals.

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Year:  1987        PMID： 2879568     DOI： 10.1016/0005-2760(87)90125-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  41 in total

1.  Role of free radicals and antioxidants in the pathogenesis of the inflammatory periodontal diseases.

Authors:  I L Chapple
Journal:  Clin Mol Pathol       Date:  1996-10

2.  Rapid reprogramming of haemoglobin structure-function exposes multiple dual-antimicrobial potencies.

Authors:  Ruijuan Du; Bow Ho; Jeak Ling Ding
Journal:  EMBO J       Date:  2009-12-17       Impact factor: 11.598

3.  Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages.

Authors:  Alexandr Kapralov; Irina I Vlasova; Weihong Feng; Akihiro Maeda; Karen Walson; Vladimir A Tyurin; Zhentai Huang; Rajesh K Aneja; Joseph Carcillo; Hülya Bayir; Valerian E Kagan
Journal:  J Biol Chem       Date:  2009-09-08       Impact factor: 5.157

4.  The Risk of Coronary Heart Disease Associated With Glycosylated Hemoglobin of 6.5% or Greater Is Pronounced in the Haptoglobin 2-2 Genotype.

Authors:  Leah E Cahill; Majken K Jensen; Stephanie E Chiuve; Hadar Shalom; Jennifer K Pai; Alan J Flint; Kenneth J Mukamal; Kathryn M Rexrode; Andrew P Levy; Eric B Rimm
Journal:  J Am Coll Cardiol       Date:  2015-10-20       Impact factor: 24.094

5.  Hemoglobin as a source of iron overload in multiple sclerosis: does multiple sclerosis share risk factors with vascular disorders?

Authors:  Vladimir V Bamm; George Harauz
Journal:  Cell Mol Life Sci       Date:  2014-02-07       Impact factor: 9.261

6.  Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chicken.

Authors:  Krzysztof B Wicher; Erik Fries
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-06       Impact factor: 11.205

Review 7.  Metals and lipid oxidation. Contemporary issues.

Authors:  K M Schaich
Journal:  Lipids       Date:  1992-03       Impact factor: 1.880

8.  Serum proteomic profiling and haptoglobin polymorphisms in patients with GVHD after allogeneic hematopoietic cell transplantation.

Authors:  Joseph McGuirk; Gang Hao; Weijian Hou; Sunil Abhyankar; Casey Williams; Weisi Yan; Jianda Yuan; Xiuqin Guan; Robert Belt; Shaun Dejarnette; Jeffery Wieman; Ying Yan
Journal:  J Hematol Oncol       Date:  2009-04-20       Impact factor: 17.388

9.  Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury.

Authors:  Kevin J Woollard; Sharelle Sturgeon; Jaye P F Chin-Dusting; Hatem H Salem; Shaun P Jackson
Journal:  J Biol Chem       Date:  2009-03-10       Impact factor: 5.157

10.  Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin.

Authors:  Leah E Cahill; Andrew P Levy; Stephanie E Chiuve; Majken K Jensen; Hong Wang; Nawar M Shara; Shany Blum; Barbara V Howard; Jennifer K Pai; Kenneth J Mukamal; Kathryn M Rexrode; Eric B Rimm
Journal:  J Am Coll Cardiol       Date:  2013-01-09       Impact factor: 24.094
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