Literature DB >> 2879535

Monoclonal antibodies against rat kidney gamma-glutamyl transpeptidase show species and tissue specificity.

J A Green, N D Cook, M M Manson.   

Abstract

Monoclonal antibodies have been raised against rat kidney gamma-glutamyl transpeptidase (GGT). All five antibodies immunoprecipitate enzyme activity from solubilized kidney brush-border membranes, but not from hepatocellular carcinoma membranes. Three of the antibodies react immunohistochemically with brush-border membranes in sections of adult rat kidney, but none of the antibodies cross-react with sections of guinea-pig, mouse or marmoset kidney or with untreated or carcinogen-treated rat liver. The antibodies do not recognize GGT in foetal-rat kidney and react poorly with kidney from 2-year-old rat. They do react with tubules trapped within mesenchymal kidney tumours induced by dimethylnitrosamine, but epithelial tumours, which are GGT-positive (although much less so than normal kidney), are not immunoreactive.

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Year:  1986        PMID： 2879535      PMCID： PMC1147221          DOI： 10.1042/bj2380913

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue.

Authors:  S Jaken; M Mason
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

2.  Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity.

Authors:  A M Rutenburg; H Kim; J W Fischbein; J S Hanker; H L Wasserkrug; A M Seligman
Journal:  J Histochem Cytochem       Date:  1969-08       Impact factor: 2.479

3.  Physiochemical and immunochemical characterization of gamma-glutamyl transpeptidase from yolk sak tumor and ascitic hepatoma (AH-66) cells.

Authors:  N Yokosawa; N Taniguchi; Y Tsukada; A Makita
Journal:  Oncodev Biol Med       Date:  1981

4.  Studies on the structure of gamma-glutamyltranspeptidase. I. Correlation between sialylation and isozymic forms.

Authors:  Y Matsuda; A Tsuji; N Katunuma
Journal:  J Biochem       Date:  1980-04       Impact factor: 3.387

5.  The major developmentally regulated protein complex in membranes of Dictyostelium.

Authors:  C Bordier; W F Loomis
Journal:  J Biol Chem       Date:  1978-07-25       Impact factor: 5.157

6.  Preparation of monoclonal antibodies: strategies and procedures.

Authors:  G Galfrè; C Milstein
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

7.  A monoclonal antibody against gamma-glutamyltransferase from human primary hepatoma: its use in enzyme-linked immunosorbent assay of sera of cancer patients.

Authors:  N Taniguchi; S House; N Kuzumaki; N Yokosawa; S Yamagiwa; S Iizuka; A Makita; C Sekiya
Journal:  J Natl Cancer Inst       Date:  1985-11       Impact factor: 13.506

8.  An examination of the relative resistances to aflatoxin B1 and susceptibilities to gamma-glutamyl p-phenylene diamine mustard of gamma-glutamyl transferase negative and positive cell lines.

Authors:  M M Manson; R F Legg; J V Watson; J A Green; G E Neal
Journal:  Carcinogenesis       Date:  1981       Impact factor: 4.944

9.  Subcellular localization and isolation of gamma-glutamyltransferase from rat hepatoma cells.

Authors:  J L Ding; G D Smith; T J Peters
Journal:  Biochim Biophys Acta       Date:  1981-10-13

10.  Structural studies of the carbohydrate moieties of rat kidney gamma-glutamyltranspeptidase. An extremely heterogeneous pattern enriched with nonreducing terminal N-acetylglucosamine residues.

Authors:  K Yamashita; A Hitoi; Y Matsuda; A Tsuji; N Katunuma; A Kobata
Journal:  J Biol Chem       Date:  1983-01-25       Impact factor: 5.157
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  2 in total

1.  Differential diagnosis of histogenetically distinct human epithelial renal tumours with a monoclonal antibody against gamma-glutamyltransferase.

Authors:  P Fischer; S Störkel; W Haase; J E Scherberich
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

2.  Production, cross reactivity, and epitope analysis of monoclonal antibodies against rat kidney gamma glutamyltransferase.

Authors:  J Bayad; N Sabolovic; D Bagrel; A Visvikis; M Wellman; G Siest
Journal:  Cell Biol Toxicol       Date:  1990-04       Impact factor: 6.691
  2 in total

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