Literature DB >> 28795334

Mathematical modeling of extracorporeal CO2 removal therapy : A validation carried out on ten pigs.

Simon Habran1, Thomas Desaive2, Philippe Morimont2, Bernard Lambermont3, Pierre Dauby2.   

Abstract

The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The simulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support.

Entities:  

Keywords:  Critical care; Extracorporeal lung support; Hypercapnia; Patient-specific modeling

Mesh：

Substances：

Year:  2017        PMID： 28795334     DOI： 10.1007/s11517-017-1694-y

Source DB:  PubMed          Journal:  Med Biol Eng Comput        ISSN： 0140-0118            Impact factor:   2.602


  26 in total

1.  A physiological model for extracorporeal oxygenation controller design.

Authors:  Marian Walter; Soren Weyer; Andre Stollenwerk; Rudger Kopp; Jutta Arens; Steffen Leonhardt
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2.  What's new in extracorporeal carbon dioxide removal for COPD?

Authors:  Darryl Abrams; Roberto Roncon-Albuquerque; Daniel Brodie
Journal:  Intensive Care Med       Date:  2015-02-03       Impact factor: 17.440

3.  Global and regional trends in COPD mortality, 1990-2010.

Authors:  Peter G J Burney; Jaymini Patel; Roger Newson; Cosetta Minelli; Mohsen Naghavi
Journal:  Eur Respir J       Date:  2015-04-02       Impact factor: 16.671

4.  Table of nonprotein respiratory quotient: an update.

Authors:  F Péronnet; D Massicotte
Journal:  Can J Sport Sci       Date:  1991-03

5.  A numerical model of blood oxygenation during veno-venous ECMO: analysis of the interplay between blood oxygenation and its delivery parameters.

Authors:  Elmi Messai; Abdesselam Bouguerra; Guy Harmelin; Gabriella Di Lascio; Manuela Bonizzoli; Massimo Bonacchi
Journal:  J Clin Monit Comput       Date:  2015-06-20       Impact factor: 2.502

Review 6.  Role and potentials of low-flow CO(2) removal system in mechanical ventilation.

Authors:  Pierpaolo Terragni; Giorgia Maiolo; V Marco Ranieri
Journal:  Curr Opin Crit Care       Date:  2012-02       Impact factor: 3.687

7.  Mathematical analysis and digital simulation of the respiratory control system.

Authors:  F S Grodins; J Buell; A J Bart
Journal:  J Appl Physiol       Date:  1967-02       Impact factor: 3.531

8.  The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material.

Authors:  Niall D Ferguson; Eddy Fan; Luigi Camporota; Massimo Antonelli; Antonio Anzueto; Richard Beale; Laurent Brochard; Roy Brower; Andrés Esteban; Luciano Gattinoni; Andrew Rhodes; Arthur S Slutsky; Jean-Louis Vincent; Gordon D Rubenfeld; B Taylor Thompson; V Marco Ranieri
Journal:  Intensive Care Med       Date:  2012-08-25       Impact factor: 17.440

Review 9.  Update on the role of extracorporeal CO₂ removal as an adjunct to mechanical ventilation in ARDS.

Authors:  Philippe Morimont; Andriy Batchinsky; Bernard Lambermont
Journal:  Crit Care       Date:  2015-03-16       Impact factor: 9.097

10.  Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study.

Authors:  Thomas Bein; Steffen Weber-Carstens; Anton Goldmann; Thomas Müller; Thomas Staudinger; Jörg Brederlau; Ralf Muellenbach; Rolf Dembinski; Bernhard M Graf; Marlene Wewalka; Alois Philipp; Klaus-Dieter Wernecke; Matthias Lubnow; Arthur S Slutsky
Journal:  Intensive Care Med       Date:  2013-01-10       Impact factor: 17.440
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  1 in total

1.  Extracorporeal carbon dioxide removal requirements for ultraprotective mechanical ventilation: Mathematical model predictions.

Authors:  John Kenneth Leypoldt; Jacques Goldstein; Dominique Pouchoulin; Kai Harenski
Journal:  Artif Organs       Date:  2019-12-15       Impact factor: 3.094
  1 in total

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