Literature DB >> 2879365

Effect of di(2-ethylhexyl)phthalate (DEHP) on spermatogenesis in adult rats.

D Parmar, S P Srivastava, P K Seth.   

Abstract

Oral administration of di(2-ethylhexyl)phthalate (DEHP) in doses of 250, 500, 1000 and 2000 mg/kg to adult rats for 15 days caused a significant dose dependent decrease in the sperm count of the epididymal spermatozoa. The activity of gamma-glutamyl transpeptidase (gamma GT) and lactate dehydrogenase (LDH) was significantly increased in the animals of the treated groups. An increase in the activity of beta-glucuronidase and decrease in the activity of acid phosphatase was also observed at the highest dose of DEHP. The activity of sorbitol dehydrogenase (SDH) was found to be decreased in the animals exposed to 1000 and 2000 mg/kg of DEHP. These results suggest that DEHP can affect spermatogenesis by altering the activities of the enzymes responsible for the maturation of sperms. The reduced number of sperms may be responsible for the antifertilic effects of DEHP.

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Year:  1986        PMID： 2879365     DOI： 10.1016/0300-483x(86)90091-0

Source DB:  PubMed          Journal:  Toxicology        ISSN： 0300-483X            Impact factor:   4.221


  9 in total

1.  Effect of di(2-ethylhexyl)phthalate administration on rat sperm count and on sperm metabolic enzymes.

Authors:  A Siddiqui; S P Srivastava
Journal:  Bull Environ Contam Toxicol       Date:  1992-01       Impact factor: 2.151

Review 2.  Phthalates and human health.

Authors:  R Hauser; A M Calafat
Journal:  Occup Environ Med       Date:  2005-11       Impact factor: 4.402

3.  Urinary concentrations of di(2-ethylhexyl) phthalate metabolites and serum reproductive hormones: pooled analysis of fertile and infertile men.

Authors:  Jaime Mendiola; John D Meeker; Niels Jørgensen; Anna-Maria Andersson; Fan Liu; Antonia M Calafat; J Bruce Redmon; Erma Z Drobnis; Amy E Sparks; Christina Wang; Russ Hauser; Shanna H Swan
Journal:  J Androl       Date:  2011-05-19

4.  Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men.

Authors:  J Mendiola; N Jørgensen; A-M Andersson; A M Calafat; M J Silva; J B Redmon; A Sparks; E Z Drobnis; C Wang; F Liu; S H Swan
Journal:  Int J Androl       Date:  2010-07-14

5.  Di-(2-ethylhexyl)-phthalate as plasticizer in PVC respiratory tubing systems: indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants.

Authors:  B Roth; P Herkenrath; H J Lehmann; H D Ohles; H J Hömig; G Benz-Bohm; J Kreuder; A Younossi-Hartenstein
Journal:  Eur J Pediatr       Date:  1988-01       Impact factor: 3.183

6.  Effects of co-administration of di(2-ethylhexyl)phthalate and testosterone on several parameters in the testis and pharmacokinetics of its mono-de-esterified metabolite.

Authors:  S Oishi
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

Review 7.  A systematic review on the adverse health effects of di-2-ethylhexyl phthalate.

Authors:  Maryam Zarean; Mojtaba Keikha; Parinaz Poursafa; Pooyan Khalighinejad; Mohammadmehdi Amin; Roya Kelishadi
Journal:  Environ Sci Pollut Res Int       Date:  2016-10-06       Impact factor: 4.223

8.  Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer Di(2-ethylhexyl) phthalate.

Authors:  R W Moore; T A Rudy; T M Lin; K Ko; R E Peterson
Journal:  Environ Health Perspect       Date:  2001-03       Impact factor: 9.031

9.  Comparison of tris(2-ethylhexyl) phosphate and di(2-ethylhexyl) phosphoric acid toxicities in a rat 28-day oral exposure study.

Authors:  Guillaume Pelletier; Marc Rigden; Gen Sheng Wang; Don Caldwell; Shabana Siddique; Karen Leingartner; Ivana Kosarac; Sabit Cakmak; Cariton Kubwabo
Journal:  J Appl Toxicol       Date:  2019-12-29       Impact factor: 3.446
  9 in total

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