Anca-Larisa Sandu1,2, Eric Artiges1,3, André Galinowski1, Thierry Gallarda4, Frank Bellivier5, Hervé Lemaitre1, Bernard Granger6, Damien Ringuenet7, Eleni T Tzavara1,6,8, Jean-Luc Martinot1,9, Marie-Laure Paillère Martinot1,9,10. 1. Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud-Paris Saclay, University Paris Descartes Service Hospitalier Frédéric Joliot, Orsay, France. 2. Aberdeen Biomedical Imaging Centre, Lilian Sutton Building, University of Aberdeen, Aberdeen, UK. 3. Department of Psychiatry 91G16, Orsay Hospital, Orsay, France. 4. SHU Sainte-Anne Hospital, Paris, France. 5. APHP Department of Psychiatry, Fernand Widal Hospital, Paris, France. 6. APHP Department of Psychiatry, Tarnier Hospital and University Paris Descartes, Paris, France. 7. Service de Psychiatrie et Addictologie, Hôpital Paul Brousse, APHP Villejuif, France. 8. Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1130, UPMC, Paris, France. 9. INSERM Unit 1000 at Maison de Solenn, Paris, France. 10. AP-HP Adolescents Psychopathology and Medicine Department, Maison de Solenn, Cochin Hospital and University Paris Descartes, Paris, France.
Abstract
BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented. METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates. RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres. CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.
BACKGROUND: Although treatment-resistant and nontreatment-resistant depressedpatients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented. METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates. RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres. CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.
Authors: Anca-Larisa Sandu; Gordon D Waiter; Roger T Staff; Nafeesa Nazlee; Tina Habota; Chris J McNeil; Dorota Chapko; Justin H Williams; Caroline H D Fall; Giriraj R Chandak; Shailesh Pene; Murali Krishna; Andrew M McIntosh; Heather C Whalley; Kalyanaraman Kumaran; Ghattu V Krishnaveni; Alison D Murray Journal: Sci Rep Date: 2022-06-30 Impact factor: 4.996
Authors: Konstantinos N Fountoulakis; Lakshmi N Yatham; Heinz Grunze; Eduard Vieta; Allan H Young; Pierre Blier; Mauricio Tohen; Siegfried Kasper; Hans Jurgen Moeller Journal: Int J Neuropsychopharmacol Date: 2020-04-23 Impact factor: 5.176
Authors: Oliver Profant; Antonín Škoch; Jaroslav Tintěra; Veronika Svobodová; Diana Kuchárová; Jana Svobodová Burianová; Josef Syka Journal: Front Aging Neurosci Date: 2020-12-04 Impact factor: 5.750