Literature DB >> 2879264

Human fetal substantia nigra grafted to the dopamine-denervated striatum of immunosuppressed rats: evidence for functional reinnervation.

I Strömberg, M Bygdeman, M Goldstein, A Seiger, L Olson.   

Abstract

Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70-80% in optimal cases 3-5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts.

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Year:  1986        PMID： 2879264     DOI： 10.1016/0304-3940(86)90632-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  26 in total

Review 1.  Transplantation into the human brain: present status and future possibilities.

Authors:  O Lindvall
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-06       Impact factor: 10.154

Review 2.  Transplantation of embryonic dopamine neurons: what we know from rats.

Authors:  S B Dunnett
Journal:  J Neurol       Date:  1991-04       Impact factor: 4.849

3.  Results of transplanting sections of the midbrain of human embryos into the brain of mature rats.

Authors:  I P Vasileshnikova; V A Otellin
Journal:  Neurosci Behav Physiol       Date:  1989 Sep-Oct

4.  Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease.

Authors:  T K Huffaker; B D Boss; A S Morgan; N T Neff; R E Strecker; M S Spence; R Miao
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

5.  Compensation for behavioral disorders due to administration of 6-hydroxy-dopamine in transplantation of embryonic locus coeruleus tissue in rats.

Authors:  T P Semenova; A G Bragin; N I Grishchenko; I V Nesterova; O S Vinogradova; E A Gromova
Journal:  Neurosci Behav Physiol       Date:  1989 Sep-Oct

6.  Intracerebral xenografts of human mesencephalic tissue into athymic rats: immunochemical and in vivo electrochemical studies.

Authors:  I Strömberg; P Almqvist; M Bygdeman; T E Finger; G Gerhardt; A C Granholm; T J Mahalik; A Seiger; B Hoffer; L Olson
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

7.  Basic sciences and clinical neurology: a firsthand experience.

Authors:  G Macchi
Journal:  Ital J Neurol Sci       Date:  1988-08

8.  Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus.

Authors:  I Date; K Kawamura; H Nakashima
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

9.  Human fetal spinal cord xenografts survive in the eye of athymic nude rat hosts.

Authors:  A F Henschen; I Strömberg; M Bygdeman; D Dahl; B Hoffer; A Seiger; I Olson
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

10.  Human fetal cerebellar and cortical tissue transplanted to the anterior eye chamber of athymic rats: electrophysiological and structural studies.

Authors:  P Bickford-Wimer; A C Granholm; M Bygdeman; B Hoffer; L Olson; A Seiger; I Strömberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205
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