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Literature DB >> 2879225

A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

Abstract

We describe processed RNA species generated by cleavage at poly(A) sites in the immunoglobulin mu and gamma 2b heavy-chain transcription units. These "amputated transcripts" began at the first or "secreted" poly(A) site and ended at the second or "membrane" poly(A) site. Although they were polyadenylated and apparently spliced, they were largely restricted to the nucleus. Their existence confirms that the heavy-chain mRNAs are derived from RNA cleavage at alternative poly(A) sites.

Entities: Chemical

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Year: 1986 PMID： 2879225 PMCID： PMC367262 DOI： 10.1128/mcb.6.12.4749-4752.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

29 in total

1. Hybridization of denatured RNA transferred or dotted nitrocellulose paper.

Authors: P S Thomas
Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

2. Production of RNA for secreted immunoglobulin mu chains does not require transcriptional termination 5' to the microM exons.

Authors: D J Kemp; G Morahan; A F Cowman; A W Harris
Journal: Nature Date: 1983-01-06 Impact factor: 49.962

1. The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice.

Authors: M L Peterson; R P Perry
Journal: Mol Cell Biol Date: 1989-02 Impact factor: 4.272

A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

1. Hybridization of denatured RNA transferred or dotted nitrocellulose paper.

2. Production of RNA for secreted immunoglobulin mu chains does not require transcriptional termination 5' to the microM exons.

3. Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.

Review 4. Immunoglobulin RNA rearrangements in B lymphocyte differentiation.

5. The structure of the mouse immunoglobulin in gamma 3 membrane gene segment.

6. Mode of regulation of immunoglobulin mu- and delta-chain expression varies during B-lymphocyte maturation.

7. The murine immunoglobulin alpha gene expresses multiple transcripts from a unique membrane exon.

8. Transcriptional regulation of the mu-delta heavy chain locus in normal murine B lymphocytes.

9. Changes in J chain and mu chain RNA expression as a function of B cell differentiation.

10. The nucleotide sequence of the mouse immunoglobulin epsilon gene: comparison with the human epsilon gene sequence.

1. The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice.

2. Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.

3. Splice site skipping in polyomavirus late pre-mRNA processing.

4. Splice site choice in a complex transcription unit containing multiple inefficient polyadenylation signals.