Xiurong Li1, Qingbo Jiang2, Wenhui Wu1, Xianlin Xu3, Liying Miao1, Lina Jin1, Lina Xue1, Tian Huang1, Jia Di1, Jinfeng Liu1,2,3, Xiaozhou He4,5. 1. Department of Hemodialysis, The Third Affiliated Hospital of Soochow University, Changzhou, China. 2. Department of Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, China. 3. Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, China. 4. Department of Hemodialysis, The Third Affiliated Hospital of Soochow University, Changzhou, China. 1140336250@qq.com. 5. Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, China. 1140336250@qq.com.
Abstract
BACKGROUND: Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressure and cfPWV. METHODS: We conducted a cross-sectional study in patients on maintenance hemodialysis. ABP and cfPWV were measured on a midweek interdialytic day. Associations were determined using Pearson's correlation analysis and multiple stepwise regression model. RESULTS: Systolic BPs and pulse pressures, but not diastolic BPs, were significantly and positively associated with cfPWV. In a stepwise regression model, age, diabetes mellitus and all-period systolic BP were independently associated with cfPWV. When day-time and night-time BPs were included in the analysis, respectively, only night-time systolic BP and age remained as independently associated with cfPWV. CONCLUSION: Ambulatory BPs are potent associates of cfPWV and night-time systolic BP, rather than day-time BPs, is an independently predictor of cfPWV. Our results support the view that controlling of nocturnal hypertension provides a unique cardiovascular protection effect.
BACKGROUND: Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressure and cfPWV. METHODS: We conducted a cross-sectional study in patients on maintenance hemodialysis. ABP and cfPWV were measured on a midweek interdialytic day. Associations were determined using Pearson's correlation analysis and multiple stepwise regression model. RESULTS: Systolic BPs and pulse pressures, but not diastolic BPs, were significantly and positively associated with cfPWV. In a stepwise regression model, age, diabetes mellitus and all-period systolic BP were independently associated with cfPWV. When day-time and night-time BPs were included in the analysis, respectively, only night-time systolic BP and age remained as independently associated with cfPWV. CONCLUSION: Ambulatory BPs are potent associates of cfPWV and night-time systolic BP, rather than day-time BPs, is an independently predictor of cfPWV. Our results support the view that controlling of nocturnal hypertension provides a unique cardiovascular protection effect.
Authors: E J Kim; C G Park; J S Park; S Y Suh; C U Choi; J W Kim; S H Kim; H E Lim; S W Rha; H S Seo; D J Oh Journal: J Hum Hypertens Date: 2006-11-30 Impact factor: 3.012
Authors: Michel E Safar; Jacques Blacher; Bruno Pannier; Alain P Guerin; Sylvain J Marchais; Pierre-Marie Guyonvarc'h; Gérard M London Journal: Hypertension Date: 2002-03-01 Impact factor: 10.190