Jianlin Li1, Dunren Du2, Wei Gao1, Xichun Sun3, Haizhu Xie1, Gang Zhang1, Jian Li1, Honglun Li1, Kefeng Li4. 1. Department of Radiology, Yantai Yuhuangding Hospital. 2. Department of Radiology, Yantai Laishan Branch Hospital of Yuhuangding Hospital, Medical College of Qingdao University. 3. Department of Radiology, Yantai Hospital of Traditional Chinese Medicine, Yantai, China. 4. School of Medicine, University of California, San Diego, CA, USA.
Abstract
BACKGROUND: Aphasia is one of the most disabling cognitive deficits affecting >2 million people in the USA. The neuroimaging characteristics of chronic aphasic patients (>6 months post onset) remain largely unknown. OBJECTIVE: The objective of this study was to investigate the regional signal changes of spontaneous neuronal activity of brain and the inter-regional connectivity in chronic aphasia. MATERIALS AND METHODS: Resting-state blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) was used to obtain fMRI data from 17 chronic aphasic patients and 20 healthy control subjects in a Siemens Verio 3.0T MR Scanner. The amplitude of low-frequency fluctuation (ALFF) was determined, which directly reflects the regional neuronal activity. The functional connectivity (FC) of fMRI was assessed using a seed voxel linear correlation approach. The severity of aphasia was evaluated by aphasia quotient (AQ) scores obtained from Western Aphasia Battery test. RESULTS: Compared with normal subjects, aphasic patients showed decreased ALFF values in the regions of left posterior middle temporal gyrus (PMTG), left medial prefrontal gyrus, and right cerebellum. The ALFF values in left PMTG showed strong positive correlation with the AQ score (coefficient r=0.79, P<0.05). There was a positive FC in chronic aphasia between left PMTG and left inferior temporal gyrus (BA20), fusiform gyrus (BA37), and inferior frontal gyrus (BA47\45\44). CONCLUSION: Left PMTG might play an important role in language dysfunction of chronic aphasia, and ALFF value might be a promising indicator to evaluate the severity of aphasia.
BACKGROUND:Aphasia is one of the most disabling cognitive deficits affecting >2 million people in the USA. The neuroimaging characteristics of chronic aphasic patients (>6 months post onset) remain largely unknown. OBJECTIVE: The objective of this study was to investigate the regional signal changes of spontaneous neuronal activity of brain and the inter-regional connectivity in chronic aphasia. MATERIALS AND METHODS: Resting-state blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) was used to obtain fMRI data from 17 chronic aphasic patients and 20 healthy control subjects in a Siemens Verio 3.0T MR Scanner. The amplitude of low-frequency fluctuation (ALFF) was determined, which directly reflects the regional neuronal activity. The functional connectivity (FC) of fMRI was assessed using a seed voxel linear correlation approach. The severity of aphasia was evaluated by aphasia quotient (AQ) scores obtained from Western Aphasia Battery test. RESULTS: Compared with normal subjects, aphasic patients showed decreased ALFF values in the regions of left posterior middle temporal gyrus (PMTG), left medial prefrontal gyrus, and right cerebellum. The ALFF values in left PMTG showed strong positive correlation with the AQ score (coefficient r=0.79, P<0.05). There was a positive FC in chronic aphasia between left PMTG and left inferior temporal gyrus (BA20), fusiform gyrus (BA37), and inferior frontal gyrus (BA47\45\44). CONCLUSION: Left PMTG might play an important role in language dysfunction of chronic aphasia, and ALFF value might be a promising indicator to evaluate the severity of aphasia.
Authors: Thomas Ethofer; Silke Anders; Michael Erb; Cornelia Herbert; Sarah Wiethoff; Johanna Kissler; Wolfgang Grodd; Dirk Wildgruber Journal: Neuroimage Date: 2005-11-04 Impact factor: 6.556
Authors: D M Torta; T Costa; E Luda; M G Barisone; P Palmisano; S Duca; G Geminiani; F Cauda Journal: Neuroimage Clin Date: 2016-05-14 Impact factor: 4.881
Authors: Michael Iorga; James Higgins; David Caplan; Richard Zinbarg; Swathi Kiran; Cynthia K Thompson; Brenda Rapp; Todd B Parrish Journal: Sci Rep Date: 2021-04-19 Impact factor: 4.379