Michelle K McNutt1, A Cozette Kale2, Ryan S Kitagawa3, Ali H Turkmani4, David W Fields5, Sarah Baraniuk6, Brijesh S Gill7, Bryan A Cotton8, Laura J Moore9, Charles E Wade10, Arthur Day11, John B Holcomb12. 1. Department of Surgery, University of Texas Health Science Center at Houston, Memorial Hermann Hospital Red Duke Trauma Institute,United States. Electronic address: Michelle.K.McNutt@uth.tmc.edu. 2. McGovern Medical School at the University of Texas Medical School at Houston, United States. Electronic address: Alixandra.C.Kale@uth.tmc.edu. 3. Department of Neurosurgery, University of Texas Health Science Center at Houston, Mischer Neuroscience Institute, Texas Medical Center, United States. Electronic address: Ryan.S.Kitagawa@uth.tmc.edu. 4. Department of Neurosurgery, University of Texas Health Science Center at Houston, United States. Electronic address: Ali.HassounTurkmani@uth.tmc.edu. 5. McGovern Medical School at the University of Texas Medical School at Houston, United States. Electronic address: David.W.Fields@uth.tmc.edu. 6. The Center for Translational Injury Research (CeTIR), Houston, United States. Electronic address: Mary.Baraniuk@uth.tmc.edu. 7. Department of Surgery, University of Texas Health Science Center at Houston, United States. Electronic address: Brijesh.S.Gill@uth.tmc.edu. 8. Department of Surgery, University of Texas Health Science Center at Houston, Memorial Hermann Hospital Red Duke Trauma Institute,United States. Electronic address: Bryan.A.Cotton@uth.tmc.edu. 9. Department of Surgery, University of Texas Health Science Center at Houston, Memorial Hermann Hospital Red Duke Trauma Institute,United States. Electronic address: Laura.J.Moore@uth.tmc.edu. 10. Department of Surgery, University of Texas Health Science Center at Houston, The Center for Translational Injury Research (CeTIR), Houston, United States. Electronic address: Charles.E.Wade@uth.tmc.edu. 11. Department of Neurosurgery, University of Texas Health Science Center at Houston, Mischer Neuroscience Institute, Texas Medical Center, United States. Electronic address: Arthur.L.Day@uth.tmc.edu. 12. Department of Surgery, University of Texas Health Science Center at Houston, Memorial Hermann Hospital Red Duke Trauma Institute,United States. Electronic address: John.Holcomb@uth.tmc.edu.
Abstract
INTRODUCTION: Practice management guidelines for screening and treatment of patients with blunt cerebrovascular injury (BCVI) have been associated with a decreased risk of ischemic stroke. TREATMENT: of patients with BCVI and multisystem injuries that delays immediate antithrombotic therapy remains controversial. The purpose of this study was to determine the timing of BCVI treatment initiation, the incidence of stroke, and bleeding complications as a result of antithrombotic therapy in patients with isolated BCVI in comparison to those with BCVI complicated by multisystem injuries. MATERIALS AND METHODS: This study was a retrospective review of all adult blunt trauma patients admitted to a level 1 trauma center from 2009 to 2014 with a diagnosis of BCVI. RESULTS: A total of 28,305 blunt trauma patients were admitted during the study period. Of these, 323 (1.1%) had 481 BCEVIs and were separated into two groups. Isolated BCVI was reported in 111 (34.4%) patients and 212 (65.6%) patients had accompanying multisystem injuries (traumatic brain injury (TBI), solid organ injury, or spinal cord injury) that contraindicated immediate antithrombotic therapy. TREATMENT: started in patients with isolated BCVI at a median time of 30.3 (15, 52) hours after injury in contrast to 62.4 (38, 97) hours for those with multisystem injuries (p<0.001). The incidence of stroke was identical (9.9%) between groups and no bleeding complications related to antithrombotic therapy were identified. CONCLUSION: The lack of bleeding complications and equivalent stroke rates between groups suggests that the presence of TBI, solid organ injury, and spinal cord injury are not contraindications to anti-thrombotic therapy for stroke prevention in patients with BCVI.
INTRODUCTION: Practice management guidelines for screening and treatment of patients with blunt cerebrovascular injury (BCVI) have been associated with a decreased risk of ischemic stroke. TREATMENT: of patients with BCVI and multisystem injuries that delays immediate antithrombotic therapy remains controversial. The purpose of this study was to determine the timing of BCVI treatment initiation, the incidence of stroke, and bleeding complications as a result of antithrombotic therapy in patients with isolated BCVI in comparison to those with BCVI complicated by multisystem injuries. MATERIALS AND METHODS: This study was a retrospective review of all adult blunt traumapatients admitted to a level 1 trauma center from 2009 to 2014 with a diagnosis of BCVI. RESULTS: A total of 28,305 blunt traumapatients were admitted during the study period. Of these, 323 (1.1%) had 481 BCEVIs and were separated into two groups. Isolated BCVI was reported in 111 (34.4%) patients and 212 (65.6%) patients had accompanying multisystem injuries (traumatic brain injury (TBI), solid organ injury, or spinal cord injury) that contraindicated immediate antithrombotic therapy. TREATMENT: started in patients with isolated BCVI at a median time of 30.3 (15, 52) hours after injury in contrast to 62.4 (38, 97) hours for those with multisystem injuries (p<0.001). The incidence of stroke was identical (9.9%) between groups and no bleeding complications related to antithrombotic therapy were identified. CONCLUSION: The lack of bleeding complications and equivalent stroke rates between groups suggests that the presence of TBI, solid organ injury, and spinal cord injury are not contraindications to anti-thrombotic therapy for stroke prevention in patients with BCVI.
Authors: Christian D Weber; Rolf Lefering; Philipp Kobbe; Klemens Horst; Miguel Pishnamaz; Richard M Sellei; Frank Hildebrand; Hans-Christoph Pape Journal: World J Surg Date: 2018-07 Impact factor: 3.352
Authors: Christian Weber; Rolf Lefering; Philipp Kobbe; Klemens Horst; Miguel Pishnamaz; Richard Sellei; Frank Hildebrand; Hans-Christoph Pape Journal: World J Surg Date: 2018-10 Impact factor: 3.352
Authors: Christian D Weber; Rolf Lefering; Matthias S Weber; Georg Bier; Matthias Knobe; Miguel Pishnamaz; Philipp Kobbe; Frank Hildebrand Journal: World J Surg Date: 2019-09 Impact factor: 3.352
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