Romain Duprat1,2, Guo-Rong Wu1,2,3, Rudi De Raedt4, Chris Baeken1,2,5. 1. a Department of Psychiatry and Medical Psychology , Ghent University , Ghent , Belgium. 2. b Ghent Experimental Psychiatry , (GHEP) Laboratory , Ghent , Belgium. 3. c Key Laboratory of Cognition and Personality, Faculty of Psychology , Southwest University , Chongqing , China. 4. d Department of Experimental Clinical and Health Psychology , Ghent University , Ghent , Belgium. 5. e Department of Psychiatry , University Hospital (UZBrussel) , Brussels , Belgium.
Abstract
OBJECTIVES:Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDD patients. METHODS: In this registered RCT (NCT01832805), 50 MDD patients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC). Patients performed a probabilistic learning task in fMRI before and after each week of stimulation. RESULTS:Task performance analyses did not show any significant effects of aiTBS on reward responsiveness, nor differences between both groups of MDD patients. However, at baseline, low anhedonic patients displayed higher neural activity in the caudate and putamen. After the first week of aiTBS treatment, in low anhedonic patients we found a decreased neural activity within the reward system, in contrast to an increased activity observed in high anhedonic patients. No changes were observed in reward related neural regions after the first week of sham stimulation. CONCLUSIONS: Although both MDD groups showed no differences in task performance, our brain imaging findings suggest that left DLPFC aiTBS treatment modulates the reward system differently according to anhedonia severity.
RCT Entities:
OBJECTIVES: Accelerated intermittent theta-burst stimulation (aiTBS) anti-depressive working mechanisms are still unclear. Because aiTBS may work through modulating the reward system and the level of anhedonia may influence this modulation, we investigated the effect of aiTBS on reward responsiveness in high and low anhedonic MDDpatients. METHODS: In this registered RCT (NCT01832805), 50 MDDpatients were randomised to a sham-controlled cross-over aiTBS treatment protocol over the left dorsolateral prefrontal cortex (DLPFC). Patients performed a probabilistic learning task in fMRI before and after each week of stimulation. RESULTS: Task performance analyses did not show any significant effects of aiTBS on reward responsiveness, nor differences between both groups of MDDpatients. However, at baseline, low anhedonic patients displayed higher neural activity in the caudate and putamen. After the first week of aiTBS treatment, in low anhedonic patients we found a decreased neural activity within the reward system, in contrast to an increased activity observed in high anhedonic patients. No changes were observed in reward related neural regions after the first week of sham stimulation. CONCLUSIONS: Although both MDD groups showed no differences in task performance, our brain imaging findings suggest that left DLPFC aiTBS treatment modulates the reward system differently according to anhedonia severity.
Authors: A Irem Sonmez; Deniz Doruk Camsari; Aiswarya L Nandakumar; Jennifer L Vande Voort; Simon Kung; Charles P Lewis; Paul E Croarkin Journal: Psychiatry Res Date: 2018-12-07 Impact factor: 3.222
Authors: Deborah C W Klooster; Suzanne L Franklin; René M H Besseling; Jaap F A Jansen; Karen Caeyenberghs; Romain Duprat; Albert P Aldenkamp; Anton J A de Louw; Paul A J M Boon; Chris Baeken Journal: Hum Brain Mapp Date: 2018-10-01 Impact factor: 5.038